| The relation between chronic kidney disease and cerebral microbleeds: difference between patients with and without diabetes. | |
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MedLine Citation:
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PMID: 22243603 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND : Cerebral microbleeds are an important radiologic marker of bleeding-prone brain and have been reported to be associated with the increased risk of intracerebral haemorrhage. AIMS : We sought to examine the association of chronic kidney disease with cerebral microbleeds, and determine whether the association differs between patients with and without diabetes. METHODS : A total of 909 patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data (including serum creatinine levels) and documented the presence and numbers of microbleeds. Kidney function was estimated by using the Modification of Diet in Renal Disease formula. We categorized estimated glomerular filtration rates into moderate to severe, mild, and normal (<60, 60-90, and >90 ml/min/1·73 m(2) , respectively). RESULTS : Cerebral microbleeds is most frequent in the moderate-to-severe chronic kidney disease group (45·6%). In patients without diabetes, mild and moderate-to-severe chronic kidney disease was found to be independently associated with the presence of cerebral microbleeds (adjusted odds ratio, 1·68; 95% confidence interval, 1·04-2·71 and adjusted odds ratio, 3·74; 95% confidence interval, 1·87-7·47) compared with normal kidney function. In patients with diabetes, however, this relationship was not found. Furthermore, ordinal logistic regression analysis revealed that an increased serum creatinine level and a reduced kidney function were associated with the number of cerebral microbleeds. CONCLUSION : We found that chronic kidney disease is independently associated with cerebral microbleeds in patients without diabetes but not in patients with diabetes. |
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Authors:
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Wi-Sun Ryu; Seung-Hoon Lee; Chi Kyung Kim; Beom Joon Kim; Byung-Woo Yoon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-16 |
Journal Detail:
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Title: International journal of stroke : official journal of the International Stroke Society Volume: - ISSN: 1747-4949 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274068 Medline TA: Int J Stroke Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization. |
Affiliation:
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Department of Neurology, Seoul National University Hospital, Seoul, Korea; Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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