Document Detail

The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors. The LCH-Malignancy Study Group of the Histiocyte Society.
MedLine Citation:
PMID:  9561906     Owner:  NLM     Status:  MEDLINE    
The frequency of Langerhans cell histiocytosis (LCH) and a malignant neoplasm occurring in the same individual appears to be greater than previously recognized. To define the occurrence and the pattern of these events, a Study Group of the Histiocyte Society initiated a registry of patients in whom this association occurred synchronously or asynchronously. Evaluation of 54 patients detected two patterns of associations between LCH and other disorders. First, it is possible that therapy of LCH promotes a secondary malignancy. Second, it is possible that a genetic predisposition, with or without the immunosuppression associated therapy for the malignancy, plays a role in the development and expression of disseminated LCH. Data collected by the LCH-Malignancy Study Group may provide insights into the etiology and pathophysiology of LCH.
R M Egeler; J P Neglia; M Aricò; B E Favara; A Heitger; M E Nesbit; H S Nicholson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hematology/oncology clinics of North America     Volume:  12     ISSN:  0889-8588     ISO Abbreviation:  Hematol. Oncol. Clin. North Am.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-03     Completed Date:  1998-06-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709473     Medline TA:  Hematol Oncol Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-78     Citation Subset:  IM    
Southern Alberta Children's Cancer Program, Alberta Children's Hospital, Tom Baker Cancer Centre, University of Calgary, Canada.
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MeSH Terms
Child, Preschool
Histiocytosis, Langerhans-Cell / complications*,  physiopathology
Leukemia / complications*,  physiopathology
Lymphoma / complications*,  physiopathology
Neoplasms / complications*,  physiopathology

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