| The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors. The LCH-Malignancy Study Group of the Histiocyte Society. | |
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MedLine Citation:
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PMID: 9561906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The frequency of Langerhans cell histiocytosis (LCH) and a malignant neoplasm occurring in the same individual appears to be greater than previously recognized. To define the occurrence and the pattern of these events, a Study Group of the Histiocyte Society initiated a registry of patients in whom this association occurred synchronously or asynchronously. Evaluation of 54 patients detected two patterns of associations between LCH and other disorders. First, it is possible that therapy of LCH promotes a secondary malignancy. Second, it is possible that a genetic predisposition, with or without the immunosuppression associated therapy for the malignancy, plays a role in the development and expression of disseminated LCH. Data collected by the LCH-Malignancy Study Group may provide insights into the etiology and pathophysiology of LCH. |
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Authors:
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R M Egeler; J P Neglia; M Aricò; B E Favara; A Heitger; M E Nesbit; H S Nicholson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hematology/oncology clinics of North America Volume: 12 ISSN: 0889-8588 ISO Abbreviation: Hematol. Oncol. Clin. North Am. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-06-03 Completed Date: 1998-06-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8709473 Medline TA: Hematol Oncol Clin North Am Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 369-78 Citation Subset: IM |
Affiliation:
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Southern Alberta Children's Cancer Program, Alberta Children's Hospital, Tom Baker Cancer Centre, University of Calgary, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Female Histiocytosis, Langerhans-Cell / complications*, physiopathology Humans Leukemia / complications*, physiopathology Lymphoma / complications*, physiopathology Male Neoplasms / complications*, physiopathology Questionnaires |
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