| The relation of C-reactive protein to vasoocclusive crisis in children with sickle cell disease. | |
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MedLine Citation:
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PMID: 20813565 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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In view of evidence linking sickle cell anemia (SCA) with chronic inflammation, and given the role of high sensitivity C-reactive protein (hs-CRP) as inflammatory mediator, we hypothesized that SCA vasoocclusive crisis (VOC) is associated with heightened hs-CRP levels. Study subjects comprised 104 SCA patients who experienced VOC event during the study period (VOC group), and 40 SCA patients who did not develop VOC for at least 9 months prior to blood collection (Steady-state group). hs-CRP determination was done by latex-enhanced nephelometry. Higher hs-CRP levels were seen in VOC [median(range)=31.3(1.14-363.0)] than steady-state [median(range)=5(0.16-185.0)] groups (P<0.001), with enrichment in high hs-CRP percentiles in VOC cases, which translated into step-wise increased VOC risk. Receiver-operating characteristic (ROC) analysis was employed in assessing the usefulness of hs-CRP as predictor of the frequency and severity of VOC. Spearman's correlation coefficient between hs-CRP and VOC was 0.65 (P<0.001) among unselected patients (0.71 in males and 0.59 in females). hs-CRP area under ROC curves was 0.90 (95% CI=0.85-0.94) among unselected patients, 0.94 (95% CI=0.89-0.98) for males, and 0.85 (95% CI=0.77-0.93) for females. Logistic regression analysis confirmed the positive association of increased hs-CRP levels with VOC, which correlated positively with VOC frequency (P<0.001), type (P<0.001), pain (P<0.001), and need for hospitalization (P=0.024). These data support strong association of increased hs-CRP levels with VOC, which impacts VOC-related parameters, and support a role for hs-CRP in VOC follow-up. |
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Authors:
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Fatima A Mohammed; Najat Mahdi; Mai A Sater; Khadija Al-Ola; Wassim Y Almawi |
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Publication Detail:
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Type: Journal Article Date: 2010-09-01 |
Journal Detail:
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Title: Blood cells, molecules & diseases Volume: 45 ISSN: 1096-0961 ISO Abbreviation: Blood Cells Mol. Dis. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509932 Medline TA: Blood Cells Mol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 293-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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