| C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. | |
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MedLine Citation:
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PMID: 22275362 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Despite the prevalence of insulin resistance and Type 2 diabetes mellitus (T2DM), their underlying mechanisms remain incompletely understood. Many secreted endocrine factors and the inter-tissue crosstalk they mediate are known to be dysregulated in T2DM. Here, we describe CTRP12, a novel adipokine with anti-diabetic actions. The mRNA and circulating levels of CTRP12 were decreased in a mouse model of obesity, but its expression in adipocytes was increased by the anti-diabetic drug rosiglitazone. A modest rise in circulating levels of CTRP12 by recombinant protein administration was sufficient to lower blood glucose in wild-type, leptin-deficient ob/ob, and diet-induced obese (DIO) mice. A short-term elevation of serum CTRP12 by adenovirus-mediated expression improved glucose tolerance and insulin sensitivity, normalized hyperglycemia and hyperinsulinemia, and lowered postprandial insulin resistance in obese and diabetic mice. CTRP12 improves insulin sensitivity in part by enhancing insulin signaling in the liver and adipose tissue. Further, CTRP12 also acts in an insulin-independent manner; in cultured hepatocytes and adipocytes, CTRP12 directly activated the PI3K-Akt signaling pathway to suppress gluconeogenesis and promote glucose uptake, respectively. Collectively, these data establish CTRP12 as a novel metabolic regulator linking adipose tissue to whole-body glucose homeostasis through insulin-dependent and independent mechanisms. |
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Authors:
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Zhikui Wei; Jonathan M Peterson; Xia Lei; Liudmila Cebotaru; Michael J Wolfgang; G Christian Baldeviano; G William Wong |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: - ISSN: 1083-351X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Johns Hopkins University School of Medicine, United States; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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