Document Detail


Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.
MedLine Citation:
PMID:  12016119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel peptide called ghrelin or motilin-related-peptide (MTLRP) was found in the stomach of various mammals. We studied its effect on the motor function of the rat gastrointestinal tract. In normal, conscious unoperated animals, ghrelin/MTLRP (5 or 20 microg/kg iv) significantly accelerated the gastric emptying of a methylcellulose liquid solution (gastric residue after 15 min: 57 +/- 7, 42 +/- 11, 17 +/- 4, and 9 +/- 3% of the ingested meal with doses of 0, 1, 5, and 20 microg/kg iv, respectively) Transit of the methylcellulose liquid solution was also accelerated by ghrelin/MTLRP in the small intestine but not in the colon. Des-[Gln(14)]ghrelin, also found in the mammalian stomach, was as potent as ghrelin in emptying the stomach (gastric residue after 15 min: 12 +/- 3% at a dose of 20 microg/kg iv). In rats in which postoperative gastrointestinal ileus had been experimentally induced, ghrelin/MTLRP (20 microg/kg iv) reversed the delayed gastric evacuation (gastric residue after 15 min: 28 +/- 7% of the ingested meal vs. 82 +/- 9% with saline). In comparison, the gastric ileus was not modified by high doses of motilin (77 +/- 7%) or erythromycin (82 +/- 6%) and was only partially improved by calcitonin gene-related peptide (CGRP) 8-37 antagonist (59 +/- 7%). Ghrelin/MTLRP, therefore, accelerates the gastric emptying and small intestinal transit of a liquid meal and is a strong prokinetic agent capable of reversing the postoperative gastric ileus in rat.
Authors:
L Trudel; C Tomasetto; M C Rio; M Bouin; V Plourde; P Eberling; P Poitras
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  282     ISSN:  0193-1857     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-17     Completed Date:  2002-06-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G948-52     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Colon / drug effects,  physiology
Disease Models, Animal
Dose-Response Relationship, Drug
Gastric Emptying / drug effects
Gastrointestinal Motility / drug effects
Ghrelin
Intestinal Obstruction / drug therapy*
Intestine, Small / drug effects,  physiology
Male
Motilin / pharmacology*
Peptide Hormones*
Peptides / pharmacology*
Postoperative Complications / drug therapy*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 0/Peptides; 0/ghrelin, des-Gln(14)-; 52906-92-0/Motilin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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