| A reinvestigation of maximal signal drop in dynamic susceptibility contrast magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 12380480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The purpose of this study was to reevaluate the usefulness of relative maximum signal drop (rMSD), as compared to relative cerebral blood volume (rCBV) and cerebral blood flow (rCBF), in dynamic susceptibility contrast magnetic resonance imaging (MRI). METHODS: Twenty-five patients (11 with cerebral gliomas and 14 with infarcts of middle cerebral arterial territories) were included. The rMSD values were measured from 83 regions of interest and compared with measurements from corresponding rCBV and rCBF maps. RESULTS: In stroke patients, rMSD correlated strongly with rCBF (r = 0.96) but only fairly with rCBV (r = 0.69). The absence of an association between rMSD and rCBV was evident in regions of increased contrast bolus dispersion. In glioma patients, the correlation of rMSD with rCBF (r = 0.85) was similar to that of rMSD with rCBV (r = 0.80). The interparameter associations were well predicted by computer simulations. CONCLUSIONS: The authors conclude that rMSD is as useful as rCBF under a variety of pathophysiological conditions, whereas in conditions with normal mean transit time, such as brain tumors, rMSD provides equivalent blood volume information to rCBV. The simplicity of rMSD maps could lead to the increased use of perfusion-weighted MRI. |
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Authors:
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Yi-Jui Liu; Hsiao-Wen Chung; Ing-Jye Huang; Fu-Nien Wang; Shy-Chyi Chin; Chang-Shin Lee; Cheng-Yu Chen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 12 ISSN: 1051-2284 ISO Abbreviation: J Neuroimaging Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-16 Completed Date: 2002-12-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: 330-8 Citation Subset: IM |
Affiliation:
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Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain Infarction / physiopathology* Brain Mapping Brain Neoplasms / physiopathology* Cerebrovascular Circulation Computer Simulation Contrast Media Female Glioma / physiopathology* Hemodynamics Humans Magnetic Resonance Imaging / methods* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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