Document Detail


The reinforcement-enhancing effects of nicotine: implications for the relationship between smoking, eating and weight.
MedLine Citation:
PMID:  21549139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concerns about body weight represent an important barrier to public health efforts aimed at reducing smoking. Epidemiological studies have found that current smokers weigh less than non-smokers, smoking cessation results in weight gain, and weight restriction is commonly cited as a reason for smoking. The mechanisms underlying the relationship between smoking and weight are complex and may involve a number of factors including changes in caloric intake, physical activity, metabolic rate, and lipogenesis. Amongst these possible mechanisms, nicotine-induced enhancement of food reinforcement may be particularly important. In this paper, we first review data from our laboratory that highlight two distinct ways in which nicotine impacts reinforced behavior: 1) by acting as a primary reinforcer; and 2) by directly (non-associatively) enhancing the reinforcing effects of other stimuli. We then elaborate on the reinforcement-enhancing effects of nicotine as they pertain to behaviors and stimuli related to food. Data from both laboratory animals and humans support the assertion that nicotine enhances the reinforcing efficacy of food and suggest that the influence of these effects on eating may be most important after nicotine cessation when nicotine's effects on satiety subside. Finally, we discuss the theoretical and clinical implications of this perspective for understanding and addressing the apparent tradeoff between smoking and weight gain. Better understanding of the mechanisms underlying the reinforcement-enhancing effects of nicotine broadly, and the effects on food reinforcement per se, may aid in the development of new treatments with better long term outcomes.
Authors:
Eric C Donny; Anthony R Caggiula; Matthew T Weaver; Melissa E Levin; Alan F Sved
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-05-01
Journal Detail:
Title:  Physiology & behavior     Volume:  104     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-03     Completed Date:  2011-10-14     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects*
Eating / drug effects*
Feeding Behavior / drug effects
Humans
Nicotine / administration & dosage*
Reinforcement (Psychology)*
Smoking*
Grant Support
ID/Acronym/Agency:
DA 10464/DA/NIDA NIH HHS; R01 DA010464/DA/NIDA NIH HHS; R01 DA010464-14/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
54-11-5/Nicotine
Comments/Corrections

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