| A regulatory role for neurokinin B in placental physiology and pre-eclampsia. | |
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MedLine Citation:
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PMID: 11231038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tachykinin dogma has assumed, so far, that neurokinin B (NKB) is a neuropeptide that is not produced in any peripheral tissue even though its endogenous receptor, NK3, has been found in a number of locations throughout the human body. We have found an abundant source of peripheral NKB in the human and rat placenta. In this review we describe the discovery of NKB in the placenta and examine its possible role in placental physiology and pre-eclampsia (PE). Excessive secretion of placental NKB into the maternal circulation during the third trimester of pregnancy has been found in women suffering from PE. This may provide the key to the cause of the multiple and complex symptoms associated with this potentially life-threatening illness. We also reveal the structural organisation of the human NKB gene for the first time as well as discussing putative mechanisms for its control. |
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Authors:
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N M Page; R J Woods; P J Lowry |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Regulatory peptides Volume: 98 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-20 Completed Date: 2001-05-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 97-104 Citation Subset: IM |
Affiliation:
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School of Animal and Microbial Sciences, The University of Reading, RG6 6AJ, Reading, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Female Humans Molecular Sequence Data Neurokinin B / chemistry, genetics, metabolism* Placenta / physiology* Pre-Eclampsia / metabolism, physiopathology* Pregnancy Tachykinins / chemistry, genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Tachykinins; 86933-75-7/Neurokinin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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