Document Detail

The regulatory role of mitochondria in capacitative calcium entry.
MedLine Citation:
PMID:  16777055     Owner:  NLM     Status:  MEDLINE    
Capacitative regulation of calcium entry is a major mechanism of Ca2+ influx into electrically non-excitable cells, but it also operates in some excitable ones. It participates in the refilling of intracellular calcium stores and in the generation of Ca2+ signals in excited cells. The mechanism which couples depletion of intracellular calcium stores located in the endoplasmic reticulum with opening of store-operated calcium channels in the plasma membrane is not clearly understood. Mitochondria located in close proximity to Ca2+ channels are exposed to high Ca2+ concentration, and therefore, they are able to accumulate this cation effectively. This decreases local Ca2+ concentration and thereby affects calcium-dependent processes, such as depletion and refilling of the intracellular calcium stores and opening of the store-operated channels. Finally, mitochondria modulate the intensity and the duration of calcium signals induced by extracellular stimuli. Ca2+ uptake by mitochondria requires these organelles to be in the energized state. On the other hand, Ca2+ flux into mitochondria stimulates energy metabolism. To sum up, mitochondria couple cellular metabolism with calcium homeostasis and signaling.
Jerzy Duszyński; Rafał Kozieł; Wojciech Brutkowski; Joanna Szczepanowska; Krzysztof Zabłocki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-05-04
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1757     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-07-10     Completed Date:  2006-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  380-7     Citation Subset:  IM    
Nencki Institute of Experimental Biology, 3 Pasteur Str., 02-093 Warsaw, Poland.
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MeSH Terms
Calcium / physiology*
Calcium Channels / physiology
Calcium Signaling
Cell Membrane / metabolism
Cytosol / metabolism
Endoplasmic Reticulum / metabolism
Mitochondria / physiology*
Signal Transduction
Reg. No./Substance:
0/Calcium Channels; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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