Document Detail

A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity.
MedLine Citation:
PMID:  10904119     Owner:  NLM     Status:  MEDLINE    
This study presents preliminary evidence of an association between polymorphic variation in the gene for monoamine oxidase-A (MAOA) and interindividual variability in aggressiveness, impulsivity and central nervous system (CNS) serotonergic responsivity. An apparently functional 30-bp VNTR in the promoter region of the X-chromosomal MAOA gene (MAOA-uVNTR), as well as a dinucleotide repeat in intron 2 (MAOA-CAn), was genotyped in a community sample of 110 men. All participants had completed standard interview and questionnaire measures of impulsivity, hostility and lifetime aggression history; in a majority of subjects (n=75), central serotonergic activity was also assessed by neuropsychopharmacologic challenge (prolactin response to fenfluramine hydrochloride). The four repeat variants of the MAOA-uVNTR polymorphism were grouped for analysis (alleles '1+ 4' vs. '2+3') based on prior evidence of enhanced transcriptional activity in MAOA promoter constructs with alleles 2 and 3 (repeats of intermediate length). Men in the 1/4 allele group scored significantly lower on a composite measure of dispositional aggressiveness and impulsivity (P<0.015) and showed more pronounced CNS serotonergic responsivity (P<0.02) than men in the 2/3 allele group. These associations were also significant on comparison of the more prevalent one and three alleles alone (encompassing 93% of subjects). Although in linkage disequilibrium with the MAOA-uVNTR polymorphism, MAOA-CAn repeat length variation did not vary significantly with respect to behavior or fenflluramine challenge in this sample. We conclude that the MAOA-uVNTR regulatory polymorphism may contribute, in part, to individual differences in both CNS serotonergic responsivity and personality traits germane to impulse control and antagonistic behavior.
S B Manuck; J D Flory; R E Ferrell; J J Mann; M F Muldoon
Related Documents :
18068529 - Determination of ancestral allele for possible human cancer-associated polymorphisms.
8273919 - Highly polymorphic microsatellite markers in poultry.
10331609 - Possible founder effects for fraxe alleles.
15180699 - Molecular analysis of gaa repeats and four linked bi-allelic markers in and around the ...
8268919 - High resolution methylation analysis of the fmr1 gene trinucleotide repeat region in fr...
1639389 - Isolation and chromosomal assignment of 100 highly informative human simple sequence re...
21739569 - Contiguous ∼16 mb 1p36 deletion: dominant features of classical distal 1p36 monosomy wi...
20050929 - Long-term evaluation of chromosomal breakages after radioisotope synovectomy for treatm...
16877799 - Chromosome pairing in triploid intergeneric hybrids of festuca pratensis with lolium mu...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  95     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-26     Completed Date:  2000-09-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  9-23     Citation Subset:  IM    
Department of Psychology, Behavioral Physiology Laboratory, University of Pittsburgh, PA 15260, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aggression / physiology*
Brain / physiopathology*
Dinucleotide Repeats / genetics
Gene Expression Regulation, Enzymologic / physiology
Genes, Regulator / genetics*
Impulsive Behavior / genetics*,  physiopathology
Middle Aged
Minisatellite Repeats
Monoamine Oxidase / genetics*,  physiology
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic
Receptors, Serotonin / genetics*,  physiology
Serotonin / physiology
Grant Support
Reg. No./Substance:
0/Receptors, Serotonin; 50-67-9/Serotonin; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Search for the influence of the tyrosine hydroxylase (TCAT)(n) repeat polymorphism on personality tr...
Next Document:  Antidepressant treatment during social challenge prior to 1 year of age affects immune and endocrine...