| The regulatory effects of whey retentate from bifidobacteria fermented milk on the microbiota of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME). | |
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MedLine Citation:
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PMID: 11851820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate the effects of whey retentate from Bifidobacteria fermented milk. METHODS AND RESULTS: The simulator of the human intestinal microbial ecosystem (SHIME) was used. The composition of the microbiota and its metabolic activities were analysed. Changes in the microbial composition became apparent within 15 days of the treatment in the vessels representing the ileum and the large intestine. The whey retentate favoured the growth of endogenous bifidobacteria and induced a decrease in Bacteroides fragilis and in sulphite-reducing clostridia, especially Clostridium perfringens. After the administration was stopped, these populations tended to revert to their original levels, except for the streptococci and the staphylococci populations. The treatment also led to an increase in acetic acid, CH4 and CO2 production, suggesting overgrowth of some anaerobic bacteria. Ammonium, generally considered as undesirable, declined. CONCLUSIONS: The whey retentate clearly altered the microbial community in the SHIME. SIGNIFICANCE AND IMPACT OF THE STUDY: Whey retentate appears to exert a beneficial effect on the in vitro gastrointestinal system; these findings warrant confirmation by in vivo studies. |
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Authors:
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A T Meddah; A Yazourh; I Desmet; B Risbourg; W Verstraete; M B Romond |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied microbiology Volume: 91 ISSN: 1364-5072 ISO Abbreviation: J. Appl. Microbiol. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-02-19 Completed Date: 2002-05-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9706280 Medline TA: J Appl Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 1110-7 Citation Subset: IM |
Affiliation:
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Laboratoire d'Ecologie Microbienne et de Microbiologie, Faculté de Pharmacie, 1 rue des Louvels, 80000-Amiens, France. aicha_tirtouil@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / growth & development Bifidobacterium / metabolism* Bioreactors Ecosystem Fermentation Humans Intestines / drug effects*, microbiology* Milk / metabolism, microbiology* Milk Proteins / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Milk Proteins; 0/whey protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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