| The regulation and turnover of mitochondrial uncoupling proteins. | |
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MedLine Citation:
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PMID: 20211596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel metabolism and as attenuators of reactive oxygen species production through strong or mild uncoupling. The generic function and broad tissue distribution of the uncoupling protein family means that they are increasingly implicated in a range of pathophysiological processes including obesity, insulin resistance and diabetes mellitus, neurodegeneration, cardiovascular disease, immunity and cancer. The significant recent progress describing the turnover of novel uncoupling proteins, as well as current views on the physiological roles and regulation of UCPs, is outlined. |
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Authors:
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Vian Azzu; Martin Jastroch; Ajit S Divakaruni; Martin D Brand |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-03-06 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1797 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2010 Jun-Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2011-01-10 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 785-91 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. va@mrc-mbu.cam.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus / metabolism Energy Metabolism Gene Expression Humans Insulin Resistance Ion Channels / genetics, metabolism* Mitochondria / metabolism Mitochondrial Proteins / genetics, metabolism* Models, Biological Obesity / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 AG025901/AG/NIA NIH HHS; P01 AG025901-03/AG/NIA NIH HHS; P01 AG025901-04/AG/NIA NIH HHS; P30 AG025708/AG/NIA NIH HHS; P30 AG025708-04/AG/NIA NIH HHS; P30 AG025708-05/AG/NIA NIH HHS; PL1 AG032118/AG/NIA NIH HHS; R01 AG033542/AG/NIA NIH HHS; R01 AG033542-01/AG/NIA NIH HHS; UL1 DE019608-02/DE/NIDCR NIH HHS; UL1 DE019608-02S1/DE/NIDCR NIH HHS; UL1 DE019608-03/DE/NIDCR NIH HHS; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein; 0/mitochondrial uncoupling protein 2; 0/mitochondrial uncoupling protein 3 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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