Document Detail


Regulation of subcutaneous adipose tissue blood flow during exercise in humans.
MedLine Citation:
PMID:  22223450     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regulation of subcutaneous adipose tissue blood flow (ATBF) remains poorly elucidated in humans, especially during exercise. In the present study we tested the role of adenosine in the regulation of ATBF adjacent to active and inactive thigh muscles during intermittent isometric knee-extension exercise (1 s contraction followed by 2 s rest with workloads of 50, 100, and 150 N) in six healthy young women. ATBF was measured using positron emission tomography (PET) without and with unspecific adenosine receptor inhibitor theophylline infused intravenously. Adipose regions were localized from fused PET and magnetic resonance images. Blood flow in subcutaneous adipose tissue adjacent to active muscle increased from rest (1.0 ± 0.3 ml·100 g(-1)·min(-1)) to exercise (P < 0.001) and along with increasing exercise intensity (50 N = 4.1 ± 1.4, 100 N = 5.4 ± 1.8, and 150 N = 6.9 ± 3.0 ml·100 g(-1)·min(-1), P = 0.03 for the increase). In contrast, ATBF adjacent to inactive muscle remained at resting levels with all intensities (∼1.0 ± 0.5 ml·100 g(-1)·min(-1)). During exercise theophylline prevented the increase in ATBF adjacent to active muscle especially during the highest exercise intensity (50 N = 4.3 ± 1.8 ml·100 g(-1)·min(-1), 100 N = 4.0 ± 1.5 ml·100 g(-1)·min(-1), and 150 N = 4.9 ± 1.8 ml·100 g(-1)·min(-1), P = 0.06 for an overall effect) but had no effect on blood flow adjacent to inactive muscle or adipose blood flow in resting contralateral leg. In conclusion, we report in the present study that 1) blood flow in subcutaneous adipose tissue of the leg is increased from rest to exercise in an exercise intensity-dependent manner, but only in the vicinity of working muscle, and 2) adenosine receptor antagonism attenuates this blood flow enhancement at the highest exercise intensities.
Authors:
Ilkka Heinonen; Marco Bucci; Jukka Kemppainen; Juhani Knuuti; Pirjo Nuutila; Robert Boushel; Kari K Kalliokoski
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-05
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  112     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-09-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1059-63     Citation Subset:  IM    
Affiliation:
Turku PET Centre, PO Box 52, FIN-20521 Turku, Finland. ilkka.heinonen@tyks.fi
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology
Blood Pressure / drug effects,  physiology
Exercise / physiology*
Female
Heart Rate / drug effects,  physiology
Humans
Leg / blood supply*
Muscle, Skeletal / blood supply,  drug effects,  physiology
Positron-Emission Tomography / methods
Purinergic P1 Receptor Antagonists / pharmacology
Regional Blood Flow / drug effects,  physiology
Rest / physiology
Subcutaneous Fat / blood supply*,  drug effects,  physiology*
Theophylline / pharmacology
Young Adult
Chemical
Reg. No./Substance:
0/Purinergic P1 Receptor Antagonists; 58-55-9/Theophylline; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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