| The regulation of subcutaneous adipose tissue blood flow during exercise in humans. | |
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MedLine Citation:
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PMID: 22223450 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Regulation of subcutaneous adipose tissue blood flow (ATBF) remains poorly elucidated in humans, especially during exercise. In the present study we tested the role of adenosine in the regulation ATBF adjacent to active and inactive thigh muscles during intermittent isometric knee-extension exercise (1 s contraction followed by 2 s rest with workloads of 50N, 100N and 150N) in six healthy young women. ATBF was measured using positron emission tomography without and with unspecific adenosine receptor inhibitor theophylline infused intravenously. Adipose regions were localised from fused PET and MRI images. Blood flow in subcutaneous adipose tissue adjacent to active muscle increased from rest (1.0 ± 0.3 ml (.) 100g(-1) (.) min(-1)) to exercise (p < 0.001) and along with increasing exercise intensity (50N = 4.1 ± 1.4, 100N = 5.4 ± 1.8, and 150N = 6.9 ± 3.0 ml (.) 100g(-1) (.) min(-1), p = 0.03 for the increase). In contrast, ATBF adjacent to inactive muscle remained at resting levels with all intensities (~1.0 ± 0.5 ml/100g/min). During exercise theophylline prevented the increase in ATBF adjacent to active muscle especially during the highest exercise intensity (50N = 4.3 ± 1.8 ml (.) 100g(-1) (.) min(-1), 100N = 4.0 ± 1.5 ml (.) 100g(-1) (.) min(-1) and 150N = 4.9 ± 1.8 ml (.) 100g(-1) (.) min(-1), p = 0.06 for an overall effect), but had no effect on blood flow adjacent to inactive muscle, or adipose blood flow in resting contralateral leg. In conclusion, we report in the present study that 1) blood flow in subcutaneous adipose tissue of the leg is increased from rest to exercise in an exercise intensity dependent-manner, but only in the vicinity of working muscle, and 2) adenosine receptor antagonism attenuates this blood flow enhancement at the highest exercise intensities. |
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Authors:
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Ilkka Heinonen; Marco Bucci; Jukka Kemppainen; Juhani Knuuti; Pirjo Nuutila; Robert C Boushel; Kari K Kalliokoski |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-5 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Turku. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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