| The regulation of plasma relaxin levels during human pregnancy. | |
| | |
MedLine Citation:
|
PMID: 7930999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The factors that determine the circulating levels of relaxin during pregnancy have been investigated by comparing the plasma levels of relaxin throughout pregnancy in women who became pregnant spontaneously (singleton, n = 240) or following superovulation (singleton and multifetal pregnancies (two to ten conceptuses), n = 83). Some of the women with multifetal pregnancies underwent selective fetal reduction to twin pregnancies. Relaxin levels were higher at 7-34 weeks of gestation in singleton pregnancies achieved following superovulation when compared with levels in spontaneously conceived singleton pregnancies (p < 0.05-0.001). In samples obtained between 10 and 12 weeks of gestation (before fetal reduction for the multifetal pregnancies), plasma relaxin levels correlated with fetal number (r = 0.526, P = 0.0001). Reduction in fetal number to a twin pregnancy did not alter relaxin levels. These data suggest that the circulating levels of relaxin throughout pregnancy are determined during the cycle of conception by gonadotrophin stimulation, and within the first 10 weeks of pregnancy by the luteotrophic stimulus from the conceptus. Furthermore, once corpus luteum synthesis of relaxin is established, then reduction in the luteotrophic stimulus does not appear to affect it. |
| | |
Authors:
|
M R Johnson; A A Abbas; A C Allman; K H Nicolaides; S L Lightman |
Related Documents
:
|
3082379 - Prostaglandin f2 alpha as the luteolysin in swine: vi. hormonal regulation of the movem... 1149689 - The conversion of pregnenolone-7alpha-3h and progesterone-4-14c to estrogens by corpora... 1891449 - Life cycle of hepatozoon mehlhorni sp. nov. in the viper echis carinatus and the mosqui... 19754549 - The role of the ovary for the maintenance of pregnancy in cats. 8203639 - Influence of pregnancy on anf release from isolated atria. 20349379 - Aggressive behavior in two different group-housing systems for pregnant sows. 23600369 - Overexpression of cd39 protects in a mouse model of preeclampsia. 2962329 - Experimental hyperphenylalaninemia in the pregnant guinea pig: possible phenylalanine t... 21802489 - Physiological blunting during pregnancy extends to induced relaxation. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of endocrinology Volume: 142 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1994 Aug |
Date Detail:
|
Created Date: 1994-11-07 Completed Date: 1994-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 261-5 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, Chelsea and Westminister Hospital, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Corpus Luteum / metabolism Female Humans Pregnancy / blood* Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy, Multiple / blood* Relaxin / biosynthesis, blood* Superovulation / blood* |
| Chemical | |
Reg. No./Substance:
|
9002-69-1/Relaxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determination of lignans and isoflavonoids in human female plasma following dietary supplementation.
Next Document: Effects of placing micro-implants of melatonin in the pars tuberalis, pars distalis and the lateral ...