| The regulation of food intake by peptides. | |
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MedLine Citation:
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PMID: 2699189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Historically, nutrients and related metabolic signals were considered to control the onset and offset of meals. Recent research has focused upon the roles of peptides found in the gastrointestinal tract and brain as alternate controllers of these processes. During a meal, the gut secretes a variety of peptides as part of the digestive process. Some of these substances, acting as hormonal or as local signals, may also provide information which is relayed to the central nervous system, causing eating to stop and producing the sense of satiety. When administered to animals or people before a meal, exogenous cholecystokinin (CCK), the most studied of the putative satiety peptides, reduces food intake in a dose-dependent manner. Recent findings support the concept that endogenous CCK acts during meals to limit meal size, and evidence is reviewed suggesting a possible pathophysiological role for CCK in bulimia. Adiposity is also regulated via peptide hormones, especially insulin. Insulin is secreted in direct proportion to adiposity, and blood-borne insulin gains access to brain areas important in the regulation of feeding. The administration of insulin into the brain causes reduced eating and weight loss. |
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Authors:
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S C Woods; J Gibbs |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 575 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-05-18 Completed Date: 1990-05-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 236-43 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Washington, Seattle 98195. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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physiology Animals Appetite Regulation / physiology* Body Mass Index Cholecystokinin / physiology Eating Disorders / physiopathology Humans Insulin / physiology Peptides / physiology* Rats Satiation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK 17844/DK/NIDDK NIH HHS; DK 33248/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 11061-68-0/Insulin; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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