Document Detail

The regulation of blood perfusion in the renal cortex and medulla by reactive oxygen species and nitric oxide in the anaesthetised rat.
MedLine Citation:
PMID:  21827636     Owner:  NLM     Status:  Publisher    
Aims:  The regulation of blood flow through the renal medulla is important in determining blood pressure and its dysregulation in patho-physiological states, such as oxidative stress, may contribute to the development of hypertension. This investigation examined the hypothesis that reactive oxygen species has both direct and indirect actions, via scavenging NO, to determine the degree of blood perfusion through the renal medulla. Methods:  Groups of male Wistar rats received a renal interstitial infusion of either tempol, a superoxide dismutase mimetic, or tempol plus catalase (tem+cat), or diethyldithio-carbamic acid (DETC) a SOD inhibitor, or L-NAME alone or L-NAME followed by DETC. Results:  Medullary blood perfusion (MBP) increased by 16±1% (P<0.05) following the renal infusion of tempol and by 35±4%% (P<0.05) when tem+cat was infused. Cortical blood perfusion (CBP) was unchanged during the administration of tempol and tem+cat. The renal interstitial infusion of DETC reduced CBP by 13±2%, (P<0.05) and MBP by 22±3% (P<0.05). Infusion of L-NAME to block NOS did not change CBP but decreased MBP by 12±4% which was (P<0.05) less than the reduction obtained with DETC. Administration of DETC in the presence of L-NAME reduced CBP and MBP by 17 and 14%, respectively, the latter response being approximately half that obtained when only DETC was infused. Conclusions:  These findings demonstrated that both reactive oxygen species and NO determined the level of MBP. The findings support the hypothesis that reactive oxygen species can act both indirectly, via scavenging of NO, and directly via H(2) O(2) to modulate blood perfusion in the medulla.
Ahmad F Ahmeda; Edward J Johns
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-9
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Scandinavian Physiological Society.
Department of Physiology, University College Cork, Cork, Republic of Ireland.
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