| On the regulation of antipyrine and oxazepam metabolism in man. | |
| | |
MedLine Citation:
|
PMID: 461954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The metabolism of antipyrine and oxazepam has been measured in twelve healthy subjects. Antipyrine, an analgesic and antipyretic drug, is extensively metabolized by oxidation at various sites and oxazepam, a benzodiazepine, is almost exclusively metabolized by conjugation with glucuronic acid. Comparing the plasma clearance rates and the plasma half lives of the two drugs, correlation coefficients of r = 0.766 (P less than 0.01) and r = 0.966 (P less than 0.01) have been obtained. The data suggests that in man the processes of oxidation and glucuronidation are linked by a common control which regulates the metabolic rates of the two reactions. |
| | |
Authors:
|
G H Kellermann; M Luyten-Kellermann |
Related Documents
:
|
10215754 - Metabolic interactions between mibefradil and hmg-coa reductase inhibitors: an in vitro... 10725304 - Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyze... 20103974 - Nocturnal intermittent hypoxia and metabolic syndrome; the effect of being overweight: ... 21533414 - Cancer cachexia. 7043884 - Tiamulin feed premix in the prevention and control of swine dysentery under farm condit... 11913554 - Isolation of salmonella from diarrheic feces of pigs. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Research communications in chemical pathology and pharmacology Volume: 23 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1979 Feb |
Date Detail:
|
Created Date: 1979-09-17 Completed Date: 1979-09-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 287-96 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antipyrine
/
blood,
metabolism* Biotransformation Female Glucuronates / metabolism Half-Life Humans Male Oxazepam / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Glucuronates; 60-80-0/Antipyrine; 604-75-1/Oxazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Measurement of naphthoxylactic and naphtoxyacetic acid in human plasma following propranolol adminis...
Next Document: Induction of NADH-dependent aldehyde reductase by successive administration of barbiturates in rat b...