Document Detail


The regional distribution of kassinin-like immunoreactivity in central and peripheral tissues of the cat.
MedLine Citation:
PMID:  2412635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The regional distribution of kassinin-like immunoreactivity (KLI) was investigated by radioimmunoassay in central and peripheral tissues of the cat. In the cat brain KLI was found to have a widespread distribution with the highest concentrations present in the substantia nigra followed by the hypothalamus and caudate nucleus. Moderate levels were detected in the spinal cord, brainstem and thalamus but only low levels were found in the frontal cortex and cerebellum. In the periphery KLI was present in moderate amounts in the pituitary but in only low amounts in the dorsal root ganglion. KLI was present throughout the gastrointestinal tract with the highest concentration in the duodenum. The distribution of KLI was found to resemble closely that of substance P-like immunoreactivity (SPLI) although the ratio of SPLI to KLI varied widely throughout the tissues tested. In the frontal cortex and cerebellum the concentration of SPLI was at least 5-fold higher than that of KLI whereas in the pituitary gland, caudate nucleus and terminal ileum the concentrations of SPLI were only 50% higher. High pressure liquid chromatographic analysis of individual tissue extracts was used in order to characterize the KLI. In the caudate nucleus, substantia nigra and hypothalamus the major immunoreactive peak co-eluted with synthetic substance K. In contrast, in the spinal cord and terminal ileum the major peak of KLI co-eluted with synthetic neuromedin K. These results demonstrate that KLI is widely distributed throughout cat tissues and that this distribution closely resembles that of SPLI. However, it also appears that there are important qualitative differences in the KLI between the areas tested.
Authors:
J C Hunter; P A Hannah; J E Maggio
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  341     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-11-04     Completed Date:  1985-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  228-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / analysis,  metabolism
Animals
Cats
Central Nervous System / analysis,  metabolism*
Chromatography, High Pressure Liquid
Digestive System / analysis,  metabolism*
Ganglia, Spinal / analysis,  metabolism
Ganglia, Sympathetic / analysis,  metabolism
Kassinin
Male
Nerve Tissue Proteins / analysis,  metabolism
Neurokinin A
Neurokinin B
Oligopeptides / analysis,  metabolism*
Radioimmunoassay
Substance P / analysis,  metabolism*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Oligopeptides; 33507-63-0/Substance P; 63968-82-1/Kassinin; 86933-74-6/Neurokinin A; 86933-75-7/Neurokinin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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