Document Detail


A region of the vertebrate neural plate in which neighbouring cells can adopt neural or epidermal fates.
MedLine Citation:
PMID:  10899008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cells in the neurogenic region of the fly, Drosophila melanogaster, become either neural stem cells or epidermis and the selection of the former requires the activity of the proneural genes [1]. In contrast, it is commonly thought that all cells in the vertebrate neural plate contribute to the neural tube and that consequently there is no need for the selection of individual neural precursors (e.g., [2]). Here we present a detailed fate map of the chick caudal neural plate (CNP), a cell population that generates the posterior hindbrain and spinal cord. We show that this is a unique region of the neural plate where neighbouring cells can contribute to neural tube or epidermis. Further, neural tube precursors leave the CNP in an approximate rostro-caudal order and give rise to discrete portions of the neural tube where they or their progeny behave as neural stem cells [3]. Our data suggest that neural and epidermal cell fates are acquired on a cell-by-cell basis within the CNP and thus in a manner strikingly similar to that in the fly. Indeed, the assignment of neural cell fate in this region may prove to be mediated by the functional homologue of the fly proneural genes (chick achaete-scute homologue 4, cash4), which is expressed heterogeneously within this cell population [4].
Authors:
J M Brown; K G Storey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current biology : CB     Volume:  10     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-18     Completed Date:  2000-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  869-72     Citation Subset:  IM    
Affiliation:
Department of Human Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo
Drosophila melanogaster / cytology,  embryology
Epidermis / cytology,  embryology
Models, Biological
Nervous System / cytology,  embryology*
Rhombencephalon / cytology,  embryology
Spinal Cord / cytology,  embryology
Stem Cells / cytology

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