Document Detail


The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients.
MedLine Citation:
PMID:  23050815     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Chronic nonhealing cutaneous wounds are a worldwide problem with no agent able to promote healing. A naturally occurring, endogenous repair molecule, thymosin beta 4 (Tβ4), has many biological activities that promote dermal repair. It is released by platelets at the site of injury and initiates the repair cascade. Tβ4 accelerated dermal healing of full-thickness punch wounds in various animal models, including normal rats and mice, steroid-treated rats, diabetic mice, and aged mice. Furthermore, in two phase 2 clinical trials of stasis and pressure ulcers, it was found to accelerate healing by almost a month in those patients that did heal. Tβ4 likely acts to repair and regenerate wounds by promoting cell migration and stem cell mobilization and differentiation, and by inhibiting inflammation, apoptosis, and infection. We conclude that Tβ4 is a multifunctional regenerative peptide important in dermal repair.
Authors:
Terry Treadwell; Hynda K Kleinman; David Crockford; Mark A Hardy; Giorgio T Guarnera; Allan L Goldstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1270     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-44     Citation Subset:  IM    
Copyright Information:
© 2012 New York Academy of Sciences.
Affiliation:
Institute for Advanced Wound Care, Montgomery, Alabama. Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC. RegeneRx Biopharmaceuticals Inc., Rockville, Maryland. Department of Surgery, Columbia University, College of Physicians and Surgeons, New York, New York. Istituto Dermatopadico dell'Immacolata, Rome, Italy.
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