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The regenerating gene iα is overexpressed in atrophic gastritis rats with hypergastrinemia.
MedLine Citation:
PMID:  21949663     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα  in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P < 0.05), while the number of glands dramatically decreased (P < 0.05). In addition, the cell proliferation in gastric glands was increased in experimental AG rats, as determined by immunohistochemistry staining of PCNA and GS II. The level of serum gastrin in AG rats was significantly elevated relative to that of normal rats (P < 0.01). Moreover, the expression of RegIα protein and its receptor mRNA was increased in gastric tissues in AG rats (P < 0.05). Taken together, we demonstrated that the overexpression of Reglα is related with hypergastrinemia in AG rats.
Authors:
Shujie Chen; Jing Zhong; Qunyan Zhou; Xiaofeng Lu; Liangjing Wang; Jianmin Si
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Publication Detail:
Type:  Journal Article     Date:  2011-09-22
Journal Detail:
Title:  Gastroenterology research and practice     Volume:  2011     ISSN:  1687-630X     ISO Abbreviation:  Gastroenterol Res Pract     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-28     Completed Date:  2011-11-10     Revised Date:  2012-04-27    
Medline Journal Info:
Nlm Unique ID:  101475557     Medline TA:  Gastroenterol Res Pract     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  403956     Citation Subset:  -    
Affiliation:
Laboratory of Digestive Disease, Sir Run Run Shaw Clinical Medicine Institution of Zhejiang University, Hangzhou 310003, China.
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