| The refluxate: The impact of its magnitude, composition and distribution. | |
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MedLine Citation:
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PMID: 21126699 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The pathogenesis of gastrointestinal reflux disease is multifactoral. Integral to the disease process is the refluxate itself. The characteristics and composition of the refluxate are dependent on several physiological variables. The refluxate may contain varying concentrations of acid, pepsin, gas, or contents of duodenal reflux (such as bile acid and pancreatic enzymes). Characteristics such as volume and proximal extent of the refluxate, and the chemical content of this refluxate can strongly influence the risk of symptom perception. Strong acid (pH<4) and duodeno-gastro-oesophageal reflux are also implicated in the development of mucosal damage in the form of oesophagitis, Barrett's metaplasia and oesophageal adenocarcinoma. The manifestation of disease, however, is not entirely reliant on the refluxate, which must be considered in the context of the genetic, environmental and psychological susceptibility of the individual. |
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Authors:
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Philip Woodland; Daniel Sifrim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Best practice & research. Clinical gastroenterology Volume: 24 ISSN: 1532-1916 ISO Abbreviation: Best Pract Res Clin Gastroenterol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120605 Medline TA: Best Pract Res Clin Gastroenterol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 861-71 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Queen Mary University of London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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