| A reexamination of false-positive rates for carcinogenesis studies. | |
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MedLine Citation:
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PMID: 6628896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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False-positive rates in the National Cancer Institute/National Toxicology Program (NCI/NTP) two-year carcinogenesis bioassay are examined. Previous studies that have reported high (20-50%) false-positive rates for these bioassays are reviewed. The decision rules used in many of these earlier investigations are far different than the procedures actually employed by the NCI/NTP in the interpretation of bioassay data. Data from 25 recent NTP feeding studies are examined, and the statistical significance of observed tumor increases are compared with the final interpretations regarding the carcinogenic effects of the chemicals under study. Based on this examination, a more realistic decision procedure is formulated. It is shown that under the assumption of a statistical decision rule which appears to mimic more closely the scientific judgment process, the actual overall false-positive rate in NCI/NTP bioassays appears to be no greater than 7% to 8%. |
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Authors:
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J K Haseman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fundamental and applied toxicology : official journal of the Society of Toxicology Volume: 3 ISSN: 0272-0590 ISO Abbreviation: Fundam Appl Toxicol Publication Date: 1983 Jul-Aug |
Date Detail:
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Created Date: 1983-12-20 Completed Date: 1983-12-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8200838 Medline TA: Fundam Appl Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 334-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinogens* False Positive Reactions Female Male Mice Rats Rats, Inbred F344 Species Specificity Toxicology / methods* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens |
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