Document Detail

A reexamination of false-positive rates for carcinogenesis studies.
MedLine Citation:
PMID:  6628896     Owner:  NLM     Status:  MEDLINE    
False-positive rates in the National Cancer Institute/National Toxicology Program (NCI/NTP) two-year carcinogenesis bioassay are examined. Previous studies that have reported high (20-50%) false-positive rates for these bioassays are reviewed. The decision rules used in many of these earlier investigations are far different than the procedures actually employed by the NCI/NTP in the interpretation of bioassay data. Data from 25 recent NTP feeding studies are examined, and the statistical significance of observed tumor increases are compared with the final interpretations regarding the carcinogenic effects of the chemicals under study. Based on this examination, a more realistic decision procedure is formulated. It is shown that under the assumption of a statistical decision rule which appears to mimic more closely the scientific judgment process, the actual overall false-positive rate in NCI/NTP bioassays appears to be no greater than 7% to 8%.
J K Haseman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fundamental and applied toxicology : official journal of the Society of Toxicology     Volume:  3     ISSN:  0272-0590     ISO Abbreviation:  Fundam Appl Toxicol     Publication Date:    1983 Jul-Aug
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8200838     Medline TA:  Fundam Appl Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-9     Citation Subset:  IM    
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MeSH Terms
False Positive Reactions
Rats, Inbred F344
Species Specificity
Toxicology / methods*
Reg. No./Substance:

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