| The reduction of superoxide dismutase activity is associated with the severity of neurological soft signs in patients with schizophrenia. | |
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MedLine Citation:
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PMID: 22658981 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study aimed to explore the relationship between antioxidant enzyme activities and neurological soft signs (NSS) in a sample of patients with schizophrenia. Sixty clinically stable patients with schizophrenia treated mostly by first-generation antipsychotics and 30 matched healthy controls were recruited. NSS were assessed in two groups by a standardised neurological examination (Krebs et al., 2000). The Red Blood Cell (RBC) antioxidant activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) were measured by spectrophotometry. RBC activities of all enzymes studied: SOD, GSH-Px and CAT, were significantly lower in the patients compared to control group. All NSS scores were significantly higher in the patients compared to healthy controls' scores. In the patients, a negative correlation was found between RBC SOD activity and NSS total score and motor coordination and motor integration sub-scores. The association between low SOD activity as a marker of oxidative stress and NSS in schizophrenic patients suggests a common pathological process of these abnormalities. |
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Authors:
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Monia Raffa; Chiraz Fendri; Leila Ben Othmen; Héla Slama; Montassar Amri; Abdelhamid Kerkeni; Anwar Mechri |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-30 |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: - ISSN: 1878-4216 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-6-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Research Laboratory "Trace Elements, Free Radicals and Antioxidants", Biophysics Department, Faculty of Medicine, 5000 Monastir, Tunisia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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