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The reduction of superoxide dismutase activity is associated with the severity of neurological soft signs in patients with schizophrenia.
MedLine Citation:
PMID:  22658981     Owner:  NLM     Status:  Publisher    
This study aimed to explore the relationship between antioxidant enzyme activities and neurological soft signs (NSS) in a sample of patients with schizophrenia. Sixty clinically stable patients with schizophrenia treated mostly by first-generation antipsychotics and 30 matched healthy controls were recruited. NSS were assessed in two groups by a standardised neurological examination (Krebs et al., 2000). The Red Blood Cell (RBC) antioxidant activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) were measured by spectrophotometry. RBC activities of all enzymes studied: SOD, GSH-Px and CAT, were significantly lower in the patients compared to control group. All NSS scores were significantly higher in the patients compared to healthy controls' scores. In the patients, a negative correlation was found between RBC SOD activity and NSS total score and motor coordination and motor integration sub-scores. The association between low SOD activity as a marker of oxidative stress and NSS in schizophrenic patients suggests a common pathological process of these abnormalities.
Monia Raffa; Chiraz Fendri; Leila Ben Othmen; Héla Slama; Montassar Amri; Abdelhamid Kerkeni; Anwar Mechri
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-30
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  -     ISSN:  1878-4216     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Research Laboratory "Trace Elements, Free Radicals and Antioxidants", Biophysics Department, Faculty of Medicine, 5000 Monastir, Tunisia.
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