Document Detail

A reduction in dietary saturated fat decreases body fat content in overweight, hypercholesterolemic males.
MedLine Citation:
PMID:  14717059     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: The effect of the quality of dietary fat on body composition is unknown. Our objective was to determine whether body composition is modified by the isocaloric substitution of a diet rich in saturated fat by a diet high in monounsaturated fat (Mediterranean diet) or a carbohydrate-rich diet in overweight subjects with hypercholesterolemia. METHODS AND RESULTS: The study involved 34 hypercholesterolemic males aged 18-63 years with a body mass index (BMI) of 28.2 (2.6), all of whom consumed a diet rich in saturated fat (SAT) for 28 days. They were then randomly divided into two groups of 17 subjects and underwent two dietary periods of 28 days each in a crossover design: a Mediterranean diet high in monounsaturated fat (MONO) and a carbohydrate-rich diet (CHO). The order of the diets was different for the two group. The CHO diet contained 57% CHO and 28% total fat (< 10% saturated fat, 12% monounsaturated fat and 6% polyunsaturated fat); the Mediterranean diet contained 47% CHO and 38% fat (< 10% saturated fat, 22% monounsaturated fat--75% of which was provided by olive oil- and 6% polyunsaturated fat). The variables measured at the end of each dietary intervention period were: 1) body composition by means of bioelectrical impedance; 2) plasma lipoproteins using enzymatic techniques; and 3) fatty acids in cholesterol esters by means of gas chromatography. BMI and the waist/hip ratio remained the same during the three dietary periods. A decrease in fat was observed when changing from a saturated fat diet (23.3 (6.3) kg) to a Mediterranean diet (20.8 (7.2) kg) (p < 0.05), or a carbohydrate-rich diet (20.6 (6.7) kg) (p < 0.05). Lean mass increased when changing from a SAT diet (58.4 (7.0) kg) to a CHO diet (60.2 (7.0) kg) (p < 0.05). CONCLUSION: The isocaloric substitution of a saturated fat-rich diet by a Mediterranean or carbohydrate-rich diet decreases total body fat in hypercholesterolemic males.
R A Fernández de la Puebla; F Fuentes; P Pérez-Martinez; E Sánchez; J A Paniagua; J López-Miranda; F Pérez-Jiménez
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  13     ISSN:  0939-4753     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-01-13     Completed Date:  2004-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Lipid and Atherosclerosis Unit, Reina Sofía Hospital, Avda. Menéndez Pidal, s/n 14004 Córdoba, Spain.
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MeSH Terms
Adipose Tissue*
Apolipoproteins B / blood
Body Composition*
Body Constitution
Body Mass Index
Cholesterol / blood
Cholesterol, LDL / blood
Cross-Over Studies
Diet, Mediterranean
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage*
Dietary Fats, Unsaturated / administration & dosage
Electric Impedance
Hypercholesterolemia / diet therapy*
Middle Aged
Reg. No./Substance:
0/Apolipoproteins B; 0/Cholesterol, LDL; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Fats, Unsaturated; 57-88-5/Cholesterol

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