Document Detail

A reduction in the correlation dimension of heartbeat intervals precedes imminent ventricular fibrillation in human subjects.
MedLine Citation:
PMID:  7679868     Owner:  NLM     Status:  MEDLINE    
Reduced reflexive control of heartbeat intervals occurs with advanced heart disease and is an independent risk factor for mortality. Based on a previous study of experimental myocardial infarction in pigs, we hypothesized that a deterministic measure of heartbeat dynamics, the correlation dimension of R-R intervals (D2), may be a better predictor of risk than a stochastic measure, such as the standard deviation (SD). We determined the point estimates of the heartbeat D2 (i.e., PD2s) in Holter electrocardiographic recordings from 11 high-risk patients who manifested ventricular fibrillation (VF) during the recording and in high-risk controls having only nonsustained ventricular tachycardia (14 patients) or premature ventricular complexes (13 patients). We found that PD2 reduction (i.e., PD2s < 1.2) precedes lethal arrhythmias by hours, but is not reduced in high-risk controls (p < 0.001; sensitivity, 91%; specificity, 85%). Heartbeat SD did not discriminate among the patients. Thus PD2 of heartbeat intervals may provide an important diagnostic test and early warning sign of VF.
J E Skinner; C M Pratt; T Vybiral
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  125     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-03-25     Completed Date:  1993-03-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  731-43     Citation Subset:  AIM; IM    
Department of Neurology, Baylor College of Medicine, Houston, TX.
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MeSH Terms
Cardiac Complexes, Premature / epidemiology
Death, Sudden, Cardiac / epidemiology
Electrocardiography, Ambulatory*
Heart Rate / physiology*
Middle Aged
Predictive Value of Tests
Risk Factors
Sensitivity and Specificity
Signal Processing, Computer-Assisted*
Stroke Volume / physiology
Tachycardia, Ventricular / epidemiology
Time Factors
Ventricular Fibrillation / diagnosis,  epidemiology*
Grant Support

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