| A reduced serum level of total osteocalcin in men predicts development of diabetes in a long-term follow-up cohort. | |
| | |
MedLine Citation:
|
PMID: 21916911 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Osteocalcin (OC), an osteoblast-specific protein, has been demonstrated to affect glucose metabolism in both animals and humans. Studies in animals have shown an effect of undercarboxylated OC (ucOC) on beta cell proliferation and insulin resistance. It remains unclear whether OC is associated with the future development of diabetes in humans, as well as the relative importance of ucOC versus OC. Objective: The aim of the present study was to examine serum osteocalcin and its posttranslational forms as potential biomarkers for future development of type 2 diabetes. Methods: This was a nested case-control study using data from the Electricity Generating Authority of Thailand (EGAT). We identified 63 men without diabetes in the exploratory cohort at baseline who developed type 2 diabetes (DM) during the 10-year follow-up period from 1998-2008, and also 63 men age- and BMI-matched for a non-diabetes control group (non-DM). Serum N-mid OC and ucOC were measured in baseline blood samples. Logistic regression models were used to explore and identify baseline factors, including OC and ucOC, that predicted the subsequent development of diabetes. Results: The mean age and BMI were similar in both non-DM and DM groups (47.2 ± 0.5 vs. 47.8 ± 0.8 years, and 25.2 ± 0.5 vs. 25.9 ± 0.5 kg/m(2) , respectively). Only baseline mean serum N-mid OC (15.2 ± 0.5 vs. 13.0 ± 0.5 μg/L, P < 0.05) and fasting plasma glucose (4.92 ± 0.04 vs. 5.28 ± 0.07 mmol/L, P < 0.05) were significantly different between the two groups. Multiple logistic regression analysis showed that baseline serum N-mid OC and glucose, but not ucOC, were independent risk factors for development of diabetes in this long-term study cohort. Conclusions: Circulating total OC is associated with incident diabetes in males. Further studies to evaluate the potential utility of OC as a biomarker to predict the development of type 2 diabetes are warranted. |
| | |
Authors:
|
Chardpraorn Ngarmukos; La-Or Chailurkit; Suwanee Chanprasertyothin; Bunlue Hengprasith; Piyamitr Sritara; Boonsong Ongphiphadhanakul |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-14 |
Journal Detail:
|
Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Division of Endocrinology and Metabolism Division of Cardiology, Department of Medicine Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Medical and Health Office, Electricity Generating Authority of Thailand, Nonthaburi, Thailand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Distribution of CYP2C19*17 allele and genotypes in an Indian population.
Next Document: Cushing's Syndrome in Multiple Endocrine Neoplasia Type 1.