| The redox state of human serum albumin in eye diseases with and without complications. | |
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MedLine Citation:
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PMID: 20064117 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To investigate the redox state of human serum albumin concerning cysteine-34 as a possible systemic redox marker in patients with different eye diseases with and without complications and with consideration of possible effects of age. Methods: Cataract (CAT), glaucoma, age-related macular degeneration (AMD), diabetes mellitus (DM), diabetic retinopathy and hypertension were the pathologies investigated. Albumin redox state concerning cysteine-34 was measured by high-performance liquid chromatography with fluorescence detection. The separation gives three fractions: the fully reduced form containing a thiol group, the disulphide form and a higher oxidized form. Statistical analysis was done by Student's t-test, analysis of variance and stepwise regression analysis. Results: Albumin as a systemic marker for oxidative stress was shifted to a more oxidized state by DM. An even stronger shift to the oxidized form was observed in patients with proliferative diabetic retinopathy. Notably, these effects were independent from age. In contrast, CAT and AMD had no influence on serum albumin redox state. Conclusion: Serum albumin is not shifted to more oxidized forms by localized oxidative stress, but it is in systemic diseases like DM. |
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Authors:
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Karl Oettl; Gilbert Reibnegger; Otto Schmut |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta ophthalmologica Volume: 89 ISSN: 1755-3768 ISO Abbreviation: Acta Ophthalmol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101468102 Medline TA: Acta Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: e174-9 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal compilation © 2010 Acta Ophthalmol. |
Affiliation:
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Institute of Physiological Chemistry, Center for Physiological Medicine, Medical University of Graz, Graz, Austria University Eye Hospital, Medical University of Graz, Graz, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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