| On the redox control of B lymphocyte differentiation and function. | |
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MedLine Citation:
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PMID: 22229488 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Significance: On the one hand, redox emerges as a key mechanism in regulating intra- and inter-cellular signaling and homeostatic systems. On the other hand, cells of the B lineage provide powerful systems to unravel the intra- and inter-cellular mechanisms that coordinate the processes of development and terminal differentiation. Recent Advances: This essay summarizes a few paradigmatic examples of redox regulation and signal modulation that emerged from, or were confirmed by, studies on the development, differentiation and function of B cells. Critical Issues: While a role for intra- and inter-cellular redox signaling has been firmly established for differentiating B cells, many fundamental questions remain open including the cellular sources of reactive oxygen species (ROS), the spatial and temporal constraints of ROS signaling, the functional role of the anti-oxidant response. Future Directions: Given their robustness and biotechnological and clinical interest, cells of the B lineage continue to be fruitful goldmines from which redox biologists can dig novel mechanistic knowledge of general relevance. |
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Authors:
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Milena Bertolotti; Roberto Sitia; Anna Rubartelli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: - ISSN: 1557-7716 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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San Raffaele Scientific Institute, Genetics & Cell Biology, Milano, Italy; milena.bertolotti@hsr.it. |
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