| The red blood cell participates in regulation of the circulation by producing and releasing epoxyeicosatrienoic acids. | |
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MedLine Citation:
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PMID: 22178722 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Red blood cells (RBCs) have an important function in regulation of the circulation by producing and releasing epoxyeicosatrienoic acids (EETs) in response to a low O(2) environment such as encountered in the cardiac microcirculation during exercise. RBCs, in their role as sensors of low pO(2), release ATP and critical lipid mediators, the EETs. Both cis- and trans-EETs are synthesized and stored in RBCs and are hydrolyzed by soluble epoxide hydrolases (sEH). The trans-EETs differ from cis-EETs in their higher vascular potencies and more rapid metabolism by sEH. Thus, inhibition of sEH results in greater trans-EET levels and increased positive vascular effects of trans-EETs vs cis-EETs. The trans-EETs are responsible for a significant decline in the elevated blood pressure in the spontaneously hypertensive rat on treatment with a sEH inhibitor to raise EET levels. We predict that trans-EETs and cis-EETs will occupy important therapeutic roles in a broad spectrum of diseases and abnormal physiological conditions such as that resulting from high salt intake and hypertension. |
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Authors:
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Houli Jiang; Gail D Anderson; John C McGiff |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-8 |
Journal Detail:
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Title: Prostaglandins & other lipid mediators Volume: - ISSN: 1098-8823 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808648 Medline TA: Prostaglandins Other Lipid Mediat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Pharmacology, New York Medical College, Valhalla, NY, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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