Document Detail


A recombinant-based ELISA evaluating the efficacy of netobimin and albendazole in ruminants with naturally acquired fascioliasis.
MedLine Citation:
PMID:  19524206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The therapeutic efficacy of albendazole and netobimin in ruminants with naturally occurring fascioliasis was investigated using a recombinant-based ELISA. The variation in the IgG response against a 2.9-kDa recombinant protein (FhrAPS), termed efficacy index (EI) 1, and the egg-output changes, termed EI 2, were used to evaluate drug efficacy. The values of EI 1 ranged between 0% and 50% in sheep, and between 0% and 30% in cattle after treatment with albendazole and netobimin. Similar EI 2 values were observed in sheep receiving albendazole or netobimin, but the highest values were found in cattle treated with netobimin. The significant reduction in the IgG response to FhrAPS found in this study shows promise in terms of developing alternative methods for evaluating the efficacy of chemotherapy against Fasciola hepatica in grazing ruminants.
Authors:
María Sol Arias; José Luis Suárez; G V Hillyer; Iván Francisco; Enrique Calvo; Rita Sánchez-Andrade; Pablo Díaz; Rubén Francisco; Pablo Díez-Baños; Patrocinio Morrondo; Adolfo Paz-Silva
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  182     ISSN:  1532-2971     ISO Abbreviation:  Vet. J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-07-22     Revised Date:  2009-08-20    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
Affiliation:
Animal Pathology Department, Epidemiology, Zoonoses and Parasitic Diseases, Veterinary Faculty, Santiago de Compostela University, 27002 Lugo, Spain.
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MeSH Terms
Descriptor/Qualifier:
Albendazole / therapeutic use*
Animals
Anthelmintics / therapeutic use*
Antibodies, Helminth / blood,  immunology
Cattle
Cattle Diseases / drug therapy*
Enzyme-Linked Immunosorbent Assay / standards,  veterinary*
Fasciola hepatica / immunology
Fascioliasis / drug therapy,  veterinary*
Feces / parasitology
Female
Guanidines / therapeutic use*
Helminth Proteins / immunology
Immunoglobulin G / blood,  immunology
Parasite Egg Count / veterinary
Random Allocation
Recombinant Proteins / immunology
Sensitivity and Specificity
Sheep
Sheep Diseases / drug therapy*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
G12 RR03051/RR/NCRR NIH HHS; S06 GM08224/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Antibodies, Helminth; 0/Guanidines; 0/Helminth Proteins; 0/Immunoglobulin G; 0/Recombinant Proteins; 54965-21-8/Albendazole; 88255-01-0/netobimin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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