| A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblasts. | |
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MedLine Citation:
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PMID: 8785049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurotrophin 3 (NT-3) can support the survival of some embryonic sympathetic neuroblasts before they become nerve growth factor dependent. We show that NT-3 is produced in vivo by nonneuronal cells neighboring embryonic sympathetic ganglia. NT-3 mRNA is produced by these nonneuronal cells in vitro and is up-regulated by platelet-derived growth factor, ciliary neurotrophic factor, and glial growth factor 2 (a neuregulin). Nonneuronal cell-conditioned medium promotes survival and induces TrkA expression in isolated sympathetic neuroblasts, and this activity is blocked by anti-NT-3 antibody. Neuroblasts also enhance NT-3 production by nonneural cells. Neuroblasts synthesize several forms of neuregulin, and antibodies to neuregulin attenuate the effect of the neuroblasts on the nonneuronal cells. These data suggest a reciprocal cell-cell interaction, in which neuroblast-derived neuregulins promote NT-3 production by neighboring nonneuronal cells, which in turn promotes neuroblast survival and further differentiation. |
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Authors:
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J M Verdi; A K Groves; I Fariñas; K Jones; M A Marchionni; L F Reichardt; D J Anderson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuron Volume: 16 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-09-20 Completed Date: 1996-09-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 515-27 Citation Subset: IM |
Affiliation:
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Division of Biology 216-76, California Institute of Technology, Pasadena 91125, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cell Differentiation Cell Survival / drug effects* Cells, Cultured Mice Molecular Sequence Data Nerve Growth Factors / pharmacology* Polymerase Chain Reaction RNA, Messenger / metabolism Sympathetic Nervous System / drug effects* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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P01 NS016033-180014/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors; 0/RNA, Messenger |
| Comments/Corrections | |
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