Document Detail

A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblasts.
MedLine Citation:
PMID:  8785049     Owner:  NLM     Status:  MEDLINE    
Neurotrophin 3 (NT-3) can support the survival of some embryonic sympathetic neuroblasts before they become nerve growth factor dependent. We show that NT-3 is produced in vivo by nonneuronal cells neighboring embryonic sympathetic ganglia. NT-3 mRNA is produced by these nonneuronal cells in vitro and is up-regulated by platelet-derived growth factor, ciliary neurotrophic factor, and glial growth factor 2 (a neuregulin). Nonneuronal cell-conditioned medium promotes survival and induces TrkA expression in isolated sympathetic neuroblasts, and this activity is blocked by anti-NT-3 antibody. Neuroblasts also enhance NT-3 production by nonneural cells. Neuroblasts synthesize several forms of neuregulin, and antibodies to neuregulin attenuate the effect of the neuroblasts on the nonneuronal cells. These data suggest a reciprocal cell-cell interaction, in which neuroblast-derived neuregulins promote NT-3 production by neighboring nonneuronal cells, which in turn promotes neuroblast survival and further differentiation.
J M Verdi; A K Groves; I Fariñas; K Jones; M A Marchionni; L F Reichardt; D J Anderson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  16     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-20     Completed Date:  1996-09-20     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-27     Citation Subset:  IM    
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MeSH Terms
Base Sequence
Cell Differentiation
Cell Survival / drug effects*
Cells, Cultured
Molecular Sequence Data
Nerve Growth Factors / pharmacology*
Polymerase Chain Reaction
RNA, Messenger / metabolism
Sympathetic Nervous System / drug effects*
Time Factors
Grant Support
P01 NS016033/NS/NINDS NIH HHS; P01 NS016033-180014/NS/NINDS NIH HHS
Reg. No./Substance:
0/Nerve Growth Factors; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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