Document Detail


The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats.
MedLine Citation:
PMID:  2334845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study shows that systemic capsaicin in adult rats results in a significant loss of axons in the subepidermal nerve plexus of the posterior leg but no loss of axons in the sural nerves of these same animals. These data are interpreted as indicating that the receptive part of the peripheral sensory axon is destroyed but that the cell body and most of the peripheral axon remains intact. Thus we suggest that the receptive part of the peripheral sensory axon is the most vulnerable part of the primary afferent neuron to capsaicin in these animals. These findings may explain the observation that adult rats treated with systemic capsaicin are deficient in their responses to certain painful stimuli but usually do not show obvious signs of primary afferent neuron death. We also suggest that as the dose of capsaicin is increased the whole neuron dies. It remains to be determined if the peripheral damage reported here is related to the striking loss of primary afferent markers in the dorsal horn that is also seen after this treatment.
Authors:
K Chung; C M Klein; R E Coggeshall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  511     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-14     Completed Date:  1990-06-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  222-6     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Neuroscience, University of Texas Medical Branch, Galveston 77550.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / drug effects,  ultrastructure
Capsaicin / pharmacology*
Cell Count
Female
Male
Neurons, Afferent / drug effects*,  ultrastructure
Peripheral Nerves / drug effects*,  ultrastructure
Rats
Rats, Inbred Strains
Skin / innervation*
Grant Support
ID/Acronym/Agency:
NS07185/NS/NINDS NIH HHS; NS10161/NS/NINDS NIH HHS; NS11255/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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