Document Detail


A reappraisal of the measurement of glomerular filtration rate in pre-term infants.
MedLine Citation:
PMID:  1497999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-seven single-injection polyfructosan-S (PF-S, Inutest) and 98 continuous-infusion PF-S/creatinine clearance studies were performed in 39 sick very low birth weight infants. The single-injection clearance method for measuring glomerular filtration rate has been shown to be a reliable technique if sampling is continued for 8 h or more and the PF-S (Inutest) assay is sensitive, accurate and precise. The continuous-infusion clearance method is also valid if the infusion is continued for more than 24 h and preceded by a loading dose in the form of a double-rate infusion for 8 h. Creatinine clearance is usually less than PF-S clearance, the mean ratio being 0.91, suggesting that there is some creatinine reabsorption in the renal tubule in sick very low birth weight infants.
Authors:
B H Wilkins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  6     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  323-7     Citation Subset:  IM    
Affiliation:
Department of Child Health, Bristol University, UK.
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MeSH Terms
Descriptor/Qualifier:
Creatinine / blood,  urine
Fructans / pharmacokinetics*
Glomerular Filtration Rate
Humans
Infant, Low Birth Weight / metabolism*
Infant, Newborn
Infant, Premature, Diseases / metabolism*
Inulin / pharmacokinetics
Kidney Glomerulus / metabolism
Reproducibility of Results
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Fructans; 39421-73-3/polyfructosan; 60-27-5/Creatinine; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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