| A reappraisal of the effects of ACTH on the response of the central nervous system to injury. | |
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MedLine Citation:
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PMID: 226509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ACTH possesses powerful immuno-suppressive properties and also retards healing by inhibiting fibroblast proliferation and the deposition of collagen. In the present work this hormone was used to test both the 'barrier' and 'immune' hypotheses relating to the failure of CNS regeneration after injury, dosages being administered which had been found to stimulate maximal adrenal production of glucocorticoids in control animals. Although the scarring in the CNS and the systemic humoral and cellular immune responses were significantly depressed, no increase in CNS axon growth was noted, even when large doses of thyroxine were added. We conclude that both 'immune' and 'barrier' hypotheses should be rejected, and that the beneficial effects of thyroxine treatment reported by some workers are not substantiated. |
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Authors:
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M Berry; J Knowles; P Willis; A C Riches; G P Morgans; D Steers |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of anatomy Volume: 128 ISSN: 0021-8782 ISO Abbreviation: J. Anat. Publication Date: 1979 Jun |
Date Detail:
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Created Date: 1979-12-20 Completed Date: 1979-12-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0137162 Medline TA: J Anat Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 859-71 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
/
pharmacology,
therapeutic use* Animals Antibody Formation / drug effects Brain / pathology Brain Injuries / drug therapy, immunology, physiopathology* Cell Count Immunity, Cellular / drug effects Immunosuppression Mice Nerve Regeneration / drug effects* Rats Wound Healing / drug effects |
| Chemical | |
Reg. No./Substance:
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9002-60-2/Adrenocorticotropic Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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