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A realistic large-scale model of the cerebellum granular layer predicts circuit spatio-temporal filtering properties.
MedLine Citation:
PMID:  20508743     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The way the cerebellar granular layer transforms incoming mossy fiber signals into new spike patterns to be related to Purkinje cells is not yet clear. Here, a realistic computational model of the granular layer was developed and used to address four main functional hypotheses: center-surround organization, time-windowing, high-pass filtering in responses to spike bursts and coherent oscillations in response to diffuse random activity. The model network was activated using patterns inspired by those recorded in vivo. Burst stimulation of a small mossy fiber bundle resulted in granule cell bursts delimited in time (time windowing) and space (center-surround) by network inhibition. This burst-burst transmission showed marked frequency-dependence configuring a high-pass filter with cut-off frequency around 100 Hz. The contrast between center and surround properties was regulated by the excitatory-inhibitory balance. The stronger excitation made the center more responsive to 10-50 Hz input frequencies and enhanced the granule cell output (with spikes occurring earlier and with higher frequency and number) compared to the surround. Finally, over a certain level of mossy fiber background activity, the circuit generated coherent oscillations in the theta-frequency band. All these processes were fine-tuned by NMDA and GABA-A receptor activation and neurotransmitter vesicle cycling in the cerebellar glomeruli. This model shows that available knowledge on cellular mechanisms is sufficient to unify the main functional hypotheses on the cerebellum granular layer and suggests that this network can behave as an adaptable spatio-temporal filter coordinated by theta-frequency oscillations.
Authors:
Sergio Solinas; Thierry Nieus; Egidio D'Angelo
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Publication Detail:
Type:  Journal Article     Date:  2010-05-14
Journal Detail:
Title:  Frontiers in cellular neuroscience     Volume:  4     ISSN:  1662-5102     ISO Abbreviation:  Front Cell Neurosci     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-28     Completed Date:  2011-07-14     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101477935     Medline TA:  Front Cell Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  12     Citation Subset:  -    
Affiliation:
Department of Physiology, University of Pavia and Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia Pavia, Italy.
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