| A real-life prospective health economic study of elective single embryo transfer versus two-embryo transfer in first IVF/ICSI cycles. | |
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MedLine Citation:
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PMID: 14990547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We analysed the difference in maternal, neonatal and total costs after single (SET) versus double day 3 embryo transfer (DET). METHODS: We performed a two-centre prospective study of women in their first IVF/ICSI cycle choosing between SET or DET. Infertility treatment data were gathered from a database; maternal and neonatal outcome data from a case report form (CRF); health economic data from medical acts registered in the CRF for the outpatient part and from hospital bills. SET was performed in 206/367 (56.1%) and DET in 161/367 (43.9%) women. RESULTS: In all, 367 transfers yielded 186 positive pregnancy tests, 148 ongoing pregnancies and 136 live deliveries (50.7, 40.3 and 37.1% per embryo transfer) of which 15 (11.0%) were twins. Live birth rate was 37.4% for SET, 36.6% for DET. Intention-to-treat analysis showed differences for: duration of pregnancy (SET: 39.0 +/- 1.4 versus DET: 38.3 +/- 2.2 weeks; P = 0.055), percentage prematurity (8.5 versus 23.8%; P = 0.033), percentage of neonates hospitalized (5.7 versus 17.9%; P = 0.121) and duration of neonatal hospitalization (6.3 +/- 2.2 versus 10.3 +/- 10.1 days; P = 0.01). Total cost after DET was higher (SET: 4700 +/- 3239 versus DET: 8613 +/- 10 105; P = 0.105), due to significantly higher neonatal costs (451 +/- 957 versus 3453 +/- 8154; P < 0.001) and not to differences in maternal costs (4250 +/- 2882 versus 5160 +/- 4106; P = 0.152). CONCLUSIONS: This prospective health economic study shows that transfer of a single top quality embryo is equally effective as, but substantially cheaper than, double embryo transfer in women <38 years of age in their first IVF/ICSI cycle. |
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Authors:
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J Gerris; P De Sutter; D De Neubourg; E Van Royen; J Vander Elst; K Mangelschots; M Vercruyssen; P Kok; M Elseviers; L Annemans; P Pauwels; M Dhont |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-02-27 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 19 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-22 Completed Date: 2004-11-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 917-23 Citation Subset: IM |
Affiliation:
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Centre for Reproductive Medicine, Middelheim Hospital, Lindendreef 1, 2020 Antwerp, Belgium. jan.gerris@ocmw.antwerpen.be |
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Rate Delivery, Obstetric / statistics & numerical data Embryo Transfer / economics*, statistics & numerical data Female Fertilization in Vitro* Health Care Costs* Hospitalization / economics Humans Infant, Newborn Infant, Premature Postnatal Care / economics Pregnancy Pregnancy Rate Pregnancy, Multiple* / statistics & numerical data Prospective Studies Sperm Injections, Intracytoplasmic* Twins* / statistics & numerical data |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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