Document Detail

A re-evaluation of the urinary parameters of acid production and excretion in patients with chronic renal acidosis.
MedLine Citation:
PMID:  7723250     Owner:  NLM     Status:  MEDLINE    
We have studied acid-base balance in 32 patients attending the renal clinic of Mount Sinai Hospital. The parameters of acid-base balance measured included acid production measured as urinary sulfate and organic anions, net acid excretion measured as urinary ammonia plus titratable acid minus bicarbonate, and net GI absorption of alkali measured by a new method utilizing urinary electrolytes. Net GI absorption of alkali by urinary electrolytes measures alkali addition to the body from the GI tract as well as from any other sources, including bone. All patients had a creatinine clearance less than 80 ml/min and they were divided into two groups: those with normal serum bicarbonate (Group 1; N = 12) and those with subnormal serum bicarbonate (Group 2; N = 20). Hydrogen ion balance was -0.6 +/- 9 mEq/day in the first group, while those in the second group had a hydrogen ion balance of +16 +/- 5 mEq/day. A group of 8 normal controls had a hydrogen ion balance of -0.3 +/- 5 mEq/day. When the sum of all cations was compared with the sum of all anions in the urine, a cation gap of exactly the same magnitude as the positive hydrogen ion balance was found in patients with low serum bicarbonate. In conclusion, our data show that patients with decreased GFR and low serum bicarbonate appear to have a significantly positive hydrogen ion balance. However, we believe that the positive hydrogen ion balance is only apparent, but not real for the following reasons.(ABSTRACT TRUNCATED AT 250 WORDS)
J Uribarri; H Douyon; M S Oh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  47     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  624-7     Citation Subset:  IM    
Department of Medicine, Mt. Sinai Medical Center, New York, USA.
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MeSH Terms
Acid-Base Equilibrium
Acidosis, Renal Tubular / metabolism,  urine*
Acids / metabolism,  urine*
Bicarbonates / blood
Chronic Disease
Creatinine / metabolism
Hydrogen-Ion Concentration
Middle Aged
Reg. No./Substance:
0/Acids; 0/Bicarbonates; 60-27-5/Creatinine

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