Document Detail

The rationale for caries prevention through the use of sugar substitutes.
MedLine Citation:
PMID:  3858226     Owner:  NLM     Status:  MEDLINE    
The emergence of S. mutans in the plaque flora appears to have depended upon the ability of the organism to sequester sucrose from dietary sources, particularly from between-meal, snack-type foods. S. mutans appears to have a pH optimum at about the pH required for tooth solution to begin. This specialization which makes S. mutans cariogenic, also makes it vulnerable to dietary regimens that contain few or no sucrose snacks. As snacks are consumed by youngsters, primarily for pleasure, the use of pleasant tasting sucrose substitutes, that cannot be fermented by the plaque flora and especially by S. mutans, constitutes a viable tactic for caries control. The potential of this approach was demonstrated by the 80 per cent reduction of caries relative to a sucrose control which was observed with a xylitol chewing gum in the Turku study.
W J Loesche
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International dental journal     Volume:  35     ISSN:  0020-6539     ISO Abbreviation:  Int Dent J     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-06-25     Completed Date:  1985-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374714     Medline TA:  Int Dent J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  D; IM    
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MeSH Terms
Acids / metabolism
Chewing Gum
Dental Caries / microbiology,  physiopathology,  prevention & control*
Dental Plaque / microbiology,  physiopathology
Food Habits
Hydrogen-Ion Concentration
Saliva / physiology
Streptococcus mutans / metabolism,  physiology
Sweetening Agents / therapeutic use*
Tooth Remineralization
Xylitol / therapeutic use
Reg. No./Substance:
0/Acids; 0/Chewing Gum; 0/Sweetening Agents; 87-99-0/Xylitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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