| The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase. | |
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MedLine Citation:
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PMID: 17336523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of compounds was rationally designed as inhibitors of dimer formation of the inducible isoform of nitric oxide synthase, and subsequent nitric oxide production. The conformation of two fragments obtained from a crystal structure was utilized to design a tether connecting those same two fragments. The resulting compounds were potent dimerization inhibitors that bound to the enzyme in a similar conformation as the fragments. |
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Authors:
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Marc Whitlow; Marc Adler; David Davey; Qinglan Huang; Sunil Koovakkat; John F Parkinson; Eric Pham; Mark Polokoff; Wei Xu; Shendong Yuan; Gary Phillips |
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Publication Detail:
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Type: Journal Article Date: 2007-02-09 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 17 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-06 Completed Date: 2007-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 2505-8 Citation Subset: IM |
Affiliation:
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Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Binding Sites Cell Line, Tumor Chemistry, Pharmaceutical / methods Crystallization Crystallography, X-Ray Dimerization Drug Design Enzyme Inhibitors / chemical synthesis*, pharmacology Humans Models, Chemical Molecular Conformation Nitric Oxide Synthase Type II / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; EC 1.14.13.39/Nitric Oxide Synthase Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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