| E/E' ratio is more sensitive than E/A ratio for detection of left ventricular diastolic dysfunction in patients with systemic sclerosis. | |
| | |
MedLine Citation:
|
PMID: 20576210 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To investigate the efficiency of early filling (E) and early diastolic mitral annular velocity (E') ratio (E/E' ratio) assessed by tissue Doppler imaging (TDI) on early detection of diastolic left ventricular (LV) dysfunction in systemic sclerosis (SSc) patients without congestive heart failure (CHF) symptoms. METHODS: Thirty-five Korean SSc patients without CHF symptoms and 35 healthy, age-sex matched controls were studied. Two-dimensional and M-mode echocardiography including conventional and tissue Doppler imaging was performed and pulmonary function test with diffusing capacity of lung for carbon monoxide was assessed. RESULTS: Mean E and late filling (A) ratio (E/A ratio) showed no significant difference between the two groups, while TDI showed that SSc patients had significantly elevated E/E' ratio (10.6+/-4.2 vs. 8.8+/-2.2, p=0.032), in comparison with controls. SSc patients who had taken angiotensin converting enzyme inhibitor or angiotensin II receptor blocker had significantly lower E/E' than those who had not (8.0+/-2.4 vs. 11.9+/-4.3, p=0.01). CONCLUSIONS: E/E' ratio is more sensitive than E/A ratio for identifying LV diastolic dysfunction in SSc patients without CHF symptoms. Furthermore, SSc patients who had received ACEI or ARB treatment showed significantly better preservation of LV diastolic function than those who had not received these medications. |
| | |
Authors:
|
Sang-Won Lee; Eui-Young Choi; S Y Jung; S T Choi; Soo-Kon Lee; Yong-Beom Park |
Publication Detail:
|
Type: Journal Article Date: 2010-06-10 |
Journal Detail:
|
Title: Clinical and experimental rheumatology Volume: 28 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2010 Mar-Apr |
Date Detail:
|
Created Date: 2010-08-31 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
|
Languages: eng Pagination: S12-7 Citation Subset: IM |
Affiliation:
|
Division of Rheumatology, Yonsei University College of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II Type 1 Receptor Blockers
/
therapeutic use Angiotensin-Converting Enzyme Inhibitors / therapeutic use Carbon Monoxide / diagnostic use Cardiac Output / physiology* Diastole* Echocardiography, Doppler Female Humans Male Middle Aged Respiratory Function Tests Scleroderma, Systemic / diagnosis*, physiopathology Ventricular Dysfunction, Left / diagnosis*, physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma endogenous enkephalin levels in early systemic sclerosis: clinical and laboratory association...
Next Document: Reliability and validity of the delta finger-to-palm (FTP), a new measure of finger range of motion ...