Document Detail

The lecithin/sphingomyelin ratio in cases associated with fetomaternal disease.
MedLine Citation:
PMID:  576373     Owner:  NLM     Status:  MEDLINE    
The efficacy of correlating the L/S ratio in the amniotic fluid with fetal lung maturity has been substantiated in normal pregnancies. In gestations complicated by fetomaternal diseases, however, the assay is less reliable. This study involves 555 pregnancies in which there was a significant maternal, fetal, or placental disorder. The L/S ratio was related to fetal respiratory maturity as measured by Dubowitz criteria and the occurrence of RDS. The results show that pre-eclampsia, chronic hypertension, diabetes (Class D, E, F), significant cardiovascular disease, severe hemoglobinopathies, various congenital anomalies, chronic placental insufficiency, and prolonged ruptured membranes accelerated the L/S ration. Conversely, mild diabetes (Class B, C), intrinsic renal disease, hepatitis, collagen disease, hydrops fetalis, syphilis, and toxoplasmosis were associated with a delay in the L/S ratio. A significant increase in erroneous responses was noted in these patients when the L/S ratio was correlated to infant maturity and to the incidence of RDS. Possible mechanisms for these findings are discussed.
J C Morrison; W D Whybrew; E T Bucovaz; W L Wiser; S A Fish
Related Documents :
2122373 - Postnatal development of the middle ear: areal ratios in kittens.
7748973 - The presence of prolidase activity in amniotic fluid and its evaluation as a maturity t...
21360623 - Prenatally detectable congenital heart defects in down syndrome fetuses.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  127     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amniotic Fluid / analysis*
Fetal Diseases / diagnosis
Infant, Newborn
Lung / embryology,  metabolism
Phosphatidylcholines / analysis*,  biosynthesis,  diagnostic use
Pregnancy Complications / diagnosis*
Prenatal Diagnosis / methods*
Respiratory Distress Syndrome, Newborn / diagnosis
Sphingomyelins / analysis*,  diagnostic use
Reg. No./Substance:
0/Phosphatidylcholines; 0/Sphingomyelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bromocryptine therapy in cases of amenorrhea-galactorrhea.
Next Document:  A syndrome of immunoglobulin A deficiency, diabetes mellitus, malabsorption, a common HLA haplotype....