Document Detail

The lecithin/sphingomyelin ratio in 132 insulin-dependent diabetic pregnancies.
MedLine Citation:
PMID:  345815     Owner:  NLM     Status:  MEDLINE    
A total of 228 determinations of L/S ratios were performed in 132 insulin-dependent diabetic pregnancies. A declining L/S ratio was observed in 6 per cent of the cases without adverse effects on the fetus. No significant difference in the percentage of mature L/S ratios by weeks of pregnancy was found in the different classes of diabetes. An immature L/S ratio was associated with a significant increase of low Apgar scores. At each stage of pregnancy, there was no significant difference in the percentage of mature L/S ratios according to the sex of the baby nor according to the presence or absence of polyhydramnios. Among the five infants with HMD two had a mature L/S ratio within 2 days of birth. This represents 3 per cent incidence of false-positive results. Despite this finding, we feel that the determination of L/S ratio is a useful advance in the management of diabetic pregnancies.
C Tchobroutsky; C Amiel-Tison; L Cedard; E Eschwege; J L Rouvillois; G Tchobroutsky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  130     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-05-24     Completed Date:  1978-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  754-60     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / analysis*
Apgar Score
Diabetes Mellitus / drug therapy,  metabolism*
False Positive Reactions
Hyaline Membrane Disease / diagnosis
Infant, Newborn
Insulin / therapeutic use*
Phosphatidylcholines / analysis*
Polyhydramnios / diagnosis
Pregnancy in Diabetics / drug therapy,  metabolism*
Prenatal Diagnosis*
Respiratory Distress Syndrome, Newborn / prevention & control
Sphingomyelins / analysis*
Reg. No./Substance:
0/Phosphatidylcholines; 0/Sphingomyelins; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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