Document Detail


Psma/Psa ratio evaluated by immunohistochemistry may improve diagnosis of prostate cancer.
MedLine Citation:
PMID:  24063616     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) measured in serum are not fully satisfactory as biomarkers of prostate cancer (PC). Results obtained in this article indicated that PSMA/PSA ratio evaluated by immunohistochemistry in normal prostate (NP), benign prostatic hyperplasia (BPH), and PC at the individual level could be a useful tool for diagnosis and prognosis of PC. PSMA and PSA were equally expressed in NP and the PSMA/PSA ratio was 1.22 ± 0.15. Data also indicated that PSMA/PSA ratio fluctuates in BPH and PC compared to NP. In BPH, the PSMA/PSA ratio was around 0.47 ± 0.02, whereas it's significantly increased in PC, about 4.95 ± 0.83. In parallel, the highest PSMA/PSA ratio was associated with high intratumoral angiogenesis in PC patients with (PSMA+,PSA+) profile.
Authors:
Awatef Ben Jemaa; Yosra Bouraoui; Sataa Sallami; Ahmed Banasr; Yassine Nouira; Ridha Oueslati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of immunoassay & immunochemistry     Volume:  35     ISSN:  1532-4230     ISO Abbreviation:  J Immunoassay Immunochem     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-09-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963688     Medline TA:  J Immunoassay Immunochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  48-59     Citation Subset:  IM    
Affiliation:
a Unit of Immunology and Microbiology Environmental and Carcinogenesis (IMEC), University of Carthage , Zarzouna , Tunisia.
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