| ASC/SIL ratio for cytotechnologists: A survey of its utility in clinical practice. | |
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MedLine Citation:
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PMID: 19760762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The atypical squamous cell to squamous intraepithelial lesion (ASC/SIL) ratio for cytotechnologists (CTs) may correlate with screening sensitivity in some laboratory settings. Whether this ratio can be applied to other laboratory settings is not known. We conducted a survey of nine cytology laboratories and correlated the ASC/SIL ratio of individual CTs with other laboratory characteristics. The ASC/SIL ratio for individual CTs varied from 0.6 to 4.5 (mean: 1.9, median: 1.5). The ASC/SIL ratio within individual laboratories varied up to 567%; 25/78 (32%) CTs had an ASC/SIL ratio of less than 1.5, though only three of nine laboratories had more than one CT with a ratio this low. Laboratories that used 100% location guided screening (ThinPrep Imaging System) were much less likely to have a CT with a ratio <1.5 (1/20, 5%) than laboratories that never used location guided screening (14/34, 42%; P = 0.004). In addition, the normalized variance of these same laboratories that used location guided screening was significantly lower than those that did not (normalized standard deviation 0.32 vs. 0.55, P = 0.004). The ASC/SIL ratios did not correlate with laboratory volume, individual workload, or type of specimen preparation (conventional vs. liquid based). The ASC/SIL ratio for CTs varies widely between and within laboratories, and may correlate with the use of location guided screening. Very low ASC/SIL ratios are unusual, and CTs with low ratios may warrant further evaluation. |
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Authors:
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Andrew A Renshaw; Manon Auger; George Birdsong; Edmund S Cibas; Michael Henry; Jonathan H Hughes; Ann Moriarty; William Tench; David C Wilbur; Tarik M Elsheikh |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diagnostic cytopathology Volume: 38 ISSN: 1097-0339 ISO Abbreviation: Diagn. Cytopathol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-10 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506895 Medline TA: Diagn Cytopathol Country: United States |
Other Details:
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Languages: eng Pagination: 180-3 Citation Subset: IM |
Affiliation:
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Department of Pathology, Baptist Hospital of Miami, Miami, Florida 33176, USA. andrewr@baptisthealth.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allied Health Personnel
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standards* Female Humans Mass Screening / methods, standards* Pathology, Clinical / methods, standards* Quality Assurance, Health Care / standards* Reproducibility of Results Sensitivity and Specificity Tumor Markers, Biological Uterine Cervical Neoplasms / pathology* Vaginal Smears / methods, standards* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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