| The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo. | |
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MedLine Citation:
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PMID: 19462099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ongoing efforts to unravel the origins of the cholesterol 5,6-secosterols (1a and 1b) in biological systems have revealed that the two known chemical routes to these oxysterols, ozonolysis of cholesterol (3) and Hock-cleavage of 5-alpha-hydroperoxycholesterol (4a), are distinguishable based upon the ratio of the hydrazone derivatives (2a and 2b) formed in each case and this ratio offers an insight into the chemical origin of the secosterols in vivo. |
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Authors:
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Anita D Wentworth; Byeong-Doo Song; Jorge Nieva; Asher Shafton; Sangeetha Tripurenani; Paul Wentworth |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-04-16 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: - ISSN: 1359-7345 ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-22 Completed Date: 2009-07-23 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 3098-100 Citation Subset: IM |
Affiliation:
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Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Cholesterol / chemistry* Humans Magnetic Resonance Spectroscopy Oxidation-Reduction Ozone / chemistry* Singlet Oxygen / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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AG028300/AG/NIA NIH HHS; R21 AG028300-01/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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10028-15-6/Ozone; 17778-80-2/Singlet Oxygen; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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