Document Detail

A rating system for prompt clinical diagnosis of ischemic stroke.
MedLine Citation:
PMID:  11257324     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: When a CT scan is not available, an early accurate clinical diagnosis of ischemic stroke is essential to initiate prompt therapy. Our objective was to construct a clinical index that is easy to use when stroke patients are first evaluated at the hospital, to identify those who probably are experiencing an acute ischemic episode. The study was conducted at a university-affiliated medical referral center and two community general hospitals in Mexico. METHODS: Clinical records were reviewed for 801 patients with sudden onset of a focal or global neurologic dysfunction, presumably of vascular origin lasting more than 24 h. Eligibility criteria for this study were admission to the hospital within the first 24 h after symptomatic onset, CT scan diagnosis between 24 and 72 h, and age >45 years. Ischemic stroke included cases of arterial brain infarction, while nonischemic stroke included subarachnoid or intraparenchymatous hemorrhage, mass lesion, venous infarction, and in cases without a CT scan evidence that could explain the clinical manifestations. Data excerpted for analysis were age, sex, history of diabetes mellitus or previous stroke/transient ischemic attack (TIA), time of onset of symptoms, presence of headache, vomiting, neck stiffness, hemiplegia, leukocytosis or atrial fibrillation, diastolic blood pressure, and Glasgow coma scale (GCS) rating. Two multivariable analyses were used: 1) step-wise multiple logistic regression (SMLR), and 2) conjunctive consolidation (CC). RESULTS: After appropriate exclusions, the study proceeded with 83 ischemic and 42 nonischemic stroke patients. With SMLR, six variables were selected as predictive for ischemic stroke, including neck stiffness, diastolic blood pressure, previous history of stroke/TIA, hemiplegia, GCS, and atrial fibrillation. An appropriate sum of weighted ratings had a positive predictive value (PPV) of 100% for ischemic stroke. With consolidated categories, the PPV was 97% when patients had the following: no neck stiffness; no atrial fibrillation but history of stroke/TIA and GCS > or =12, or no neck stiffness but atrial fibrillation. CONCLUSIONS: Among patients with acute stroke, clinical data can be used to identify a group with a high probability of ischemic stroke. There are slightly different results between both methods; while SMLR includes the four variables selected by CC, the latter included neither diastolic blood pressure nor hemiplegia/hemiparesia. However, CC results seem easier to understand and interpret than with SMLR.
J O Talavera; N H Wacher; F Laredo; A López; V Martínez; J González; A Lifshitz; A R Feinstein
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Archives of medical research     Volume:  31     ISSN:  0188-4409     ISO Abbreviation:  Arch. Med. Res.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-03-21     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  576-84     Citation Subset:  IM    
Unidad en Investigación Médica en Epidemiología Clínica, Coordinación de Investigación Médica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, Col. Doctores, 06725 Mexico City, D.F., Mexico.
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MeSH Terms
Acute Disease
Atrial Fibrillation
Brain Ischemia / blood,  complications,  diagnosis*,  epidemiology
Glasgow Coma Scale
Headache / etiology
Hypertension / etiology
Leukocytosis / etiology
Logistic Models
Middle Aged
Movement Disorders / etiology
Predictive Value of Tests
Retrospective Studies
Vomiting / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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