| The rate of isometric inspiratory pressure development as a measure of responsiveness to carbon dioxide in man. | |
| | |
MedLine Citation:
|
PMID: 1149395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. A technique has been developed for assessing CO2 responsiveness by measuring the maximum rate of isometric inspiratory pressure change at the mouth [(dP/dt)max.]. 2. By use of a rebreathing technique, the (dP/dt)max. response to CO2 was shown to correlate well the ventilatory response in thirty-two normal subjects. 3. The addition of an external flow resistance sufficient to reduce the ventilatory response by a mean of 33.4% produced no significant mean change in the (dP/dt)max. response in thirty subjects. 4. In six patients recovering from bronchial asthma, reduction of airways obstruction led to a mean increase in the ventilatory response of 109% without any significant mean change in the (dP/dt)max. response. 5. An increase in lung volume did not reduce the (dP/dt)max. response in five normal subjects. 6. At very high lung volumes, six normal subjects were able to develop a higher (dP/dt)max. during voluntary inspiratory efforts than has been recorded during spontaneous breathing response to CO2. 7. It is believed that (dP/dt)max. represents the initial rate of development of force by the inspiratory muscles before this can be modified by mechanical loading, proprioceptive feedback mechanisms or conscious response and can therefore be used to study changes in the motor output of the respiratory centre in response to ventilatory stimuli independently of pulmonary mechanics. |
| | |
Authors:
|
A W Matthews; J B Howell |
Related Documents
:
|
15364615 - Mechanisms of heart failure with well preserved ejection fraction in dogs following lim... 22445155 - Detecting incipient cavitation by assessing low frequency acceleration and analysis of ... 22837165 - Influence of sympathoexcitation at high altitude on cerebrovascular function and ventil... 22684995 - Cocoa, blood pressure, and vascular function. 11518825 - Tbc3711, an et(a) receptor antagonist, reduces neonatal hypoxia-induced pulmonary hyper... 12892765 - Improved outcome with novel device for low-pressure ptca in de novo and in-stent lesions. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical science and molecular medicine Volume: 49 ISSN: 0301-0538 ISO Abbreviation: Clin Sci Mol Med Publication Date: 1975 Jul |
Date Detail:
|
Created Date: 1975-10-30 Completed Date: 1975-10-30 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0367540 Medline TA: Clin Sci Mol Med Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 57-68 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Airway Obstruction / physiopathology Asthma / physiopathology* Carbon Dioxide / pharmacology* Humans Lung / physiology, physiopathology Middle Aged Partial Pressure Respiration / drug effects* |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adrenergic responses to sustained handgrip in patients with juvenile-onset-type diabetes mellitus.
Next Document: Inhibition of renin secretion in the isolated rat kidney by antidiuretic hormone.