| Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study. | |
| | |
MedLine Citation:
|
PMID: 20498466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We investigated the prenatal prevalence of congenital heart defects (CHDs) among in vitro fertilization (IVF) pregnancies at a referral program in the United States. METHODS: Study patients were referred for fetal echocardiography between April 1, 2006, and May 1, 2009, due to IVF. An IVF pregnancy was defined as a patient who conceived with IVF with or without intracytoplasmic sperm injection. Congenital heart defect odds relative to historical data were calculated by standard methods. P < .05 was considered statistically significant. RESULTS: During the study period, we performed fetal echocardiography on 749 consecutive IVF pregnancies. Overall, the frequency of CHDs was 1.1% (95% confidence interval, 0.3%-1.8%) per pregnancy. Compared to earlier historical population data, IVF pregnancies had a significantly higher risk of CHDs (odds ratios, 7.3 [3.6-14.7] and 2.9 [1.4-5.9], respectively). However, compared to more contemporary population data, there was no difference in the CHD risk between IVF gestations and naturally conceived pregnancies. Further analysis indicated that IVF twin pregnancies were as much as 12.5 (4.6-33.5) times as likely to have CHDs compared to a general population. CONCLUSIONS: In this study population, the frequency of CHDs in IVF pregnancies was higher than early historical population data; however, it was similar to that of a more contemporary general population. Further analysis showed that this increase was mainly driven by IVF twin gestations. Previous reports of increased CHD risk in pregnancies conceived via IVF may have been due, in part, to an increased frequency of higher-order pregnancies seen among these patients. |
| | |
Authors:
|
Mert Ozan Bahtiyar; Katherine Campbell; Antonette T Dulay; Olivera Kontic-Vucinic; Bevin P Weeks; Alan H Friedman; Joshua A Copel |
Related Documents
:
|
10325286 - Prenatal sonographic diagnosis of a fetal renal mesoblastic nephroma occurring after tr... 10580676 - Ultrasound guided embryo transfer significantly improves pregnancy rates in women under... 11056236 - Double (consecutive) transfer of early embryos and blastocysts: aims and results. 1915946 - The effect of embryo quality on subsequent pregnancy rates after in vitro fertilization. 15284736 - A randomized clinical trial of the intrapartum assessment of amniotic fluid volume: amn... 21331336 - Ischemic stroke during pregnancy and puerperium. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Volume: 29 ISSN: 1550-9613 ISO Abbreviation: J Ultrasound Med Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-25 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8211547 Medline TA: J Ultrasound Med Country: United States |
Other Details:
|
Languages: eng Pagination: 917-22 Citation Subset: IM |
Affiliation:
|
Section of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, PO Box 208063, New Haven, CT 06520-8063, USA. mert.bahtiyar@yale.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Case-Control Studies Diseases in Twins / epidemiology, ultrasonography Echocardiography / methods* Female Fertilization in Vitro* Heart Defects, Congenital / epidemiology, ultrasonography* Humans Pregnancy Pregnancy Outcome Pregnancy, Multiple Prevalence Risk Factors Ultrasonography, Prenatal / methods* United States / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reproducibility of placental volume and vasculature indices obtained by 3-dimensional power Doppler ...
Next Document: Value of sonohysterography in preoperative assessment of myometrial invasion for patients with endom...