Document Detail


The rate of cell growth is governed by cell cycle stage.
MedLine Citation:
PMID:  19528319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell growth is an essential requirement for cell cycle progression. While it is often held that growth is independent of cell cycle position, this relationship has not been closely scrutinized. Here we show that in budding yeast, the ability of cells to grow changes during the cell cycle. We find that cell growth is faster in cells arrested in anaphase and G1 than in other cell cycle stages. We demonstrate that the establishment of a polarized actin cytoskeleton-either as a consequence of normal cell division or through activation of the mating pheromone response-potently attenuates protein synthesis and growth. We furthermore show by population and single-cell analysis that growth varies during an unperturbed cell cycle, slowing at the time of polarized growth. Our study uncovers a fundamental relationship whereby cell cycle position regulates growth.
Authors:
Alexi I Goranov; Michael Cook; Marketa Ricicova; Giora Ben-Ari; Christian Gonzalez; Carl Hansen; Mike Tyers; Angelika Amon
Related Documents :
7171699 - Planning blocked mitosis experiments for efficient estimation of population-doubling ti...
19048389 - Gadd45-alpha and gadd45-gamma utilize p38 and jnk signaling pathways to induce cell cyc...
3795989 - Cell cycle controls in higher eukaryotic cells: resting state or a prolonged g1 period?
17466069 - The lin-35/rb and rnai pathways cooperate to regulate a key cell cycle transition in c....
1554819 - Rabbit embryo-fetal fluid decreases the cell cycle activities of du-145 cells.
21327189 - Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells.
1182679 - The effects of therapeutic radiation on colonic mucosa.
2925799 - Effects of 1,25-dihydroxyvitamin d3 on cell-cycle kinetics of t 47d human breast cancer...
14729489 - Oocyte regulation of anti-müllerian hormone expression in granulosa cells during ovari...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes & development     Volume:  23     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-06-17     Revised Date:  2010-09-24    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1408-22     Citation Subset:  IM    
Affiliation:
David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, Massachusetts 02139, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Cell Cycle / drug effects,  genetics,  physiology*
Cell Cycle Proteins / genetics
Cell Enlargement / drug effects
Cell Size
Down-Regulation / drug effects
Mutation / genetics
Pheromones / pharmacology
Saccharomyces cerevisiae / cytology*,  drug effects,  growth & development
Grant Support
ID/Acronym/Agency:
GM056800/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Actins; 0/Cell Cycle Proteins; 0/Pheromones
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphat...
Next Document:  Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesi...