| The rate of cell growth is governed by cell cycle stage. | |
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MedLine Citation:
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PMID: 19528319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell growth is an essential requirement for cell cycle progression. While it is often held that growth is independent of cell cycle position, this relationship has not been closely scrutinized. Here we show that in budding yeast, the ability of cells to grow changes during the cell cycle. We find that cell growth is faster in cells arrested in anaphase and G1 than in other cell cycle stages. We demonstrate that the establishment of a polarized actin cytoskeleton-either as a consequence of normal cell division or through activation of the mating pheromone response-potently attenuates protein synthesis and growth. We furthermore show by population and single-cell analysis that growth varies during an unperturbed cell cycle, slowing at the time of polarized growth. Our study uncovers a fundamental relationship whereby cell cycle position regulates growth. |
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Authors:
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Alexi I Goranov; Michael Cook; Marketa Ricicova; Giora Ben-Ari; Christian Gonzalez; Carl Hansen; Mike Tyers; Angelika Amon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genes & development Volume: 23 ISSN: 1549-5477 ISO Abbreviation: Genes Dev. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-16 Completed Date: 2009-06-17 Revised Date: 2010-09-24 |
Medline Journal Info:
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Nlm Unique ID: 8711660 Medline TA: Genes Dev Country: United States |
Other Details:
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Languages: eng Pagination: 1408-22 Citation Subset: IM |
Affiliation:
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David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, Massachusetts 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Cell Cycle / drug effects, genetics, physiology* Cell Cycle Proteins / genetics Cell Enlargement / drug effects Cell Size Down-Regulation / drug effects Mutation / genetics Pheromones / pharmacology Saccharomyces cerevisiae / cytology*, drug effects, growth & development |
| Grant Support | |
ID/Acronym/Agency:
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GM056800/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Cell Cycle Proteins; 0/Pheromones |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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