Document Detail

The rate of cell growth is governed by cell cycle stage.
MedLine Citation:
PMID:  19528319     Owner:  NLM     Status:  MEDLINE    
Cell growth is an essential requirement for cell cycle progression. While it is often held that growth is independent of cell cycle position, this relationship has not been closely scrutinized. Here we show that in budding yeast, the ability of cells to grow changes during the cell cycle. We find that cell growth is faster in cells arrested in anaphase and G1 than in other cell cycle stages. We demonstrate that the establishment of a polarized actin cytoskeleton-either as a consequence of normal cell division or through activation of the mating pheromone response-potently attenuates protein synthesis and growth. We furthermore show by population and single-cell analysis that growth varies during an unperturbed cell cycle, slowing at the time of polarized growth. Our study uncovers a fundamental relationship whereby cell cycle position regulates growth.
Alexi I Goranov; Michael Cook; Marketa Ricicova; Giora Ben-Ari; Christian Gonzalez; Carl Hansen; Mike Tyers; Angelika Amon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes & development     Volume:  23     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-06-17     Revised Date:  2010-09-24    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1408-22     Citation Subset:  IM    
David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, Massachusetts 02139, USA.
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MeSH Terms
Actins / metabolism
Cell Cycle / drug effects,  genetics,  physiology*
Cell Cycle Proteins / genetics
Cell Enlargement / drug effects
Cell Size
Down-Regulation / drug effects
Mutation / genetics
Pheromones / pharmacology
Saccharomyces cerevisiae / cytology*,  drug effects,  growth & development
Grant Support
GM056800/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute; //Wellcome Trust
Reg. No./Substance:
0/Actins; 0/Cell Cycle Proteins; 0/Pheromones

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